PHM 714 Exam 1 Questions And Accurate Solutions
What is responsible for bone formation? - Answer Osteblasts
RANK-L is secreted by Osteoblast
What is responsible for bone degradation (bone resorption)? - Answer Osteoclast
Rank: on the surface of the osteoclast
What are the RANKL Inhibitors? - Answer Denosumab
Xgeva
Prolia
These lead to Rapid suppression of
bone resorption.
What are the Bisphosphonates? - Answer Zoledronic Acid (Zometa, Reclast)
Pamidronate (Aredia)
Where did you see this?
"5 mg IV no less than 15 min once a year" - Answer Zoledronic Acid (Reclast)
Osteoporosis and Paget's disease
Where did you see this?
, "Advise patients to avoid invasive dental procedures during treatment" - Answer
Zoledronic Acid Pearls
Dosing for Pamidronate - Answer Multiple myeloma, osteolytic bone lesions
• 90 mg IV over 4 hours once monthly
Breast cancer, osteolytic bone metastases
• 90 mg IV over 2 hours once every 3-4 weeks
Monitoring Parameters for Bisphosponates - Answer Dental exam, Serum Calcium,
Renal Function, Serum electrolytes
What are the mechanisms of Hypercalcemia? - Answer Increased osteoclastic bone
resorption
Increased intestinal absorption of calcium
Increased renal tubular reabsorption of calcium
What are some medications that can cause hypercalcemia? - Answer Thiazides
Vitamin D
Obviously Calcium
Aluminum/Magnesium antacids
Theophylline
Tamoxifen
Lithium
Vit A
Ganciclovir
What are the general principles of Hypercalcemia treatment? - Answer Reduce PTH
What is responsible for bone formation? - Answer Osteblasts
RANK-L is secreted by Osteoblast
What is responsible for bone degradation (bone resorption)? - Answer Osteoclast
Rank: on the surface of the osteoclast
What are the RANKL Inhibitors? - Answer Denosumab
Xgeva
Prolia
These lead to Rapid suppression of
bone resorption.
What are the Bisphosphonates? - Answer Zoledronic Acid (Zometa, Reclast)
Pamidronate (Aredia)
Where did you see this?
"5 mg IV no less than 15 min once a year" - Answer Zoledronic Acid (Reclast)
Osteoporosis and Paget's disease
Where did you see this?
, "Advise patients to avoid invasive dental procedures during treatment" - Answer
Zoledronic Acid Pearls
Dosing for Pamidronate - Answer Multiple myeloma, osteolytic bone lesions
• 90 mg IV over 4 hours once monthly
Breast cancer, osteolytic bone metastases
• 90 mg IV over 2 hours once every 3-4 weeks
Monitoring Parameters for Bisphosponates - Answer Dental exam, Serum Calcium,
Renal Function, Serum electrolytes
What are the mechanisms of Hypercalcemia? - Answer Increased osteoclastic bone
resorption
Increased intestinal absorption of calcium
Increased renal tubular reabsorption of calcium
What are some medications that can cause hypercalcemia? - Answer Thiazides
Vitamin D
Obviously Calcium
Aluminum/Magnesium antacids
Theophylline
Tamoxifen
Lithium
Vit A
Ganciclovir
What are the general principles of Hypercalcemia treatment? - Answer Reduce PTH
