BLOOD GROUPS
,• All cells have inherited combination of proteins,
glycoprotein & glycolipids on their surfaces.
• These functions as antigens that enable of our immune
system to distinguish our cells from foreign invaders.
• Part of the immune system is to produced γ-globulins calle
antibodies to combat foreign invaders.
• In blood typing the antigens of RBC surface are called
agglutinogens, because they are partially responsible for RBC
agglutination I mismatched transfusions.
• The plasma antibodies that react against them are called
agglutinins
,• Carl Lansteiner in 1900 reported that human population
could be divided into 4 groups on the basis of blood types
• These blood types were named A,B,AB & O & called ABO &
Rh system
• At least 001 blood groups are known but ABO & Rh system
more important from clinical point of view. The other blood
groups are MN, Duffy,Kell, Kidd & lewis group
BLOOD GROUP SYSTEM:
• Two antigens type A & B occurs on the surface of RBCs that
cause most of the transfusion reactions.
• As these antigen are inherited , people have neither of them
on their on their cells, they have one or they have both
simultaneously
• 2 genes one on each of 2 paired chromosomes determines
the O-A-B blood type.
,• All cells have inherited combination of proteins,
glycoprotein & glycolipids on their surfaces.
• These functions as antigens that enable of our immune
system to distinguish our cells from foreign invaders.
• Part of the immune system is to produced γ-globulins calle
antibodies to combat foreign invaders.
• In blood typing the antigens of RBC surface are called
agglutinogens, because they are partially responsible for RBC
agglutination I mismatched transfusions.
• The plasma antibodies that react against them are called
agglutinins
,• Carl Lansteiner in 1900 reported that human population
could be divided into 4 groups on the basis of blood types
• These blood types were named A,B,AB & O & called ABO &
Rh system
• At least 001 blood groups are known but ABO & Rh system
more important from clinical point of view. The other blood
groups are MN, Duffy,Kell, Kidd & lewis group
BLOOD GROUP SYSTEM:
• Two antigens type A & B occurs on the surface of RBCs that
cause most of the transfusion reactions.
• As these antigen are inherited , people have neither of them
on their on their cells, they have one or they have both
simultaneously
• 2 genes one on each of 2 paired chromosomes determines
the O-A-B blood type.
