Nurs 4500 - Multiple Sclerosis Exam with Complete
Solutions
Etiology and Pathophysiology Correct-Cause is unknown.
Related to infectious, immunological, and genetic factors
Multiple genes confer susceptibility to multiple sclerosis (MS).
Susceptibility to MS appears to be inherited. First-, second-, and third-degree relatives of
patients with MS are at slightly increased risk.
What other factors can contribute to MS Correct-infection, emotional stress, pregnancy
and poor state of health
What are the signs of MS that are definable/ characterizable Correct-Characterized by
chronic inflammation, demyelination, and gliosis in the CNS
Primary neuropathological condition is an autoimmune disease orchestrated by autoreactive
T cells.
,Environmental control - virus can predipose a genticially susceptable individual by Correct-
the virus triggers an autoimmune response, activate T cells into CNS, B cell activated and
produce Ab against myelinated oligdendrocytes and stimulates an inflammatory response
Where does MS occur the most Correct-Canada
5 x more prevalent in climates further away from the equator
What age does MS typically strike Correct-onset 20-50
affects young to middle aged people
Women are affected more then men
What is MS ? Correct-Chronic, progressive, degenerative disorder of the central nervous
system (CNS)
How is MS characterized Correct-Characterized by disseminated demyelination of nerve
fibres of the brain and spinal cord
Attacks myelin sheath - progressive
, What is the most common MS Correct-RR
Remitting/ Relapsing
Etiology Correct-Activated T cells migrate to CNS, causing blood-brain disruption.
Subsequent antigen-antibody reaction leads to demyelination of axons.
Disease process of MS consists of Correct-Loss of myelin
Disappearance of oligodendrocytes (cells that produce myelin)
Proliferation of astrocytes (produced due to injury)
changes from the disease process results in plaque formation Correct-Plaques scattered
throughout the CNS
results in sclerotic plaque
the demylination and plaque show up on MRI
Solutions
Etiology and Pathophysiology Correct-Cause is unknown.
Related to infectious, immunological, and genetic factors
Multiple genes confer susceptibility to multiple sclerosis (MS).
Susceptibility to MS appears to be inherited. First-, second-, and third-degree relatives of
patients with MS are at slightly increased risk.
What other factors can contribute to MS Correct-infection, emotional stress, pregnancy
and poor state of health
What are the signs of MS that are definable/ characterizable Correct-Characterized by
chronic inflammation, demyelination, and gliosis in the CNS
Primary neuropathological condition is an autoimmune disease orchestrated by autoreactive
T cells.
,Environmental control - virus can predipose a genticially susceptable individual by Correct-
the virus triggers an autoimmune response, activate T cells into CNS, B cell activated and
produce Ab against myelinated oligdendrocytes and stimulates an inflammatory response
Where does MS occur the most Correct-Canada
5 x more prevalent in climates further away from the equator
What age does MS typically strike Correct-onset 20-50
affects young to middle aged people
Women are affected more then men
What is MS ? Correct-Chronic, progressive, degenerative disorder of the central nervous
system (CNS)
How is MS characterized Correct-Characterized by disseminated demyelination of nerve
fibres of the brain and spinal cord
Attacks myelin sheath - progressive
, What is the most common MS Correct-RR
Remitting/ Relapsing
Etiology Correct-Activated T cells migrate to CNS, causing blood-brain disruption.
Subsequent antigen-antibody reaction leads to demyelination of axons.
Disease process of MS consists of Correct-Loss of myelin
Disappearance of oligodendrocytes (cells that produce myelin)
Proliferation of astrocytes (produced due to injury)
changes from the disease process results in plaque formation Correct-Plaques scattered
throughout the CNS
results in sclerotic plaque
the demylination and plaque show up on MRI
