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NR566 Week 6 CNS/Seizures Questions & Answers(GRADED A+)

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Seizure medications work through 5 mechanisms including: - ANSWER Stop sodium influx Stop Calcium influx Promote potassium efflux Antagonize glutamate Potentiate Gamma-Aminobutyric Acid Common adverse effects if Phenytoin (Dilantin) level 20mcg/mL include: - ANSWER Nystagmus Sedation Ataxia (staggering gait) Diplopia (double vision) Cognitive impairment Common side effects of Phenytoin (Dilantin) - ANSWER Sedation and other CNS effects, nystagmus (20) Gingival hyperplasia (oral hygiene & folic acid) Morbilliform rash - advance to SJS or TEN, Hypersensitivity with systemic involvement (DRESS) (X HLA-B 1502 genetic mutation) Cardia

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NR566 Week 6 CNS/Seizures
Questions &
Answers(GRADED A+)
Seizure medications work through 5 mechanisms including: - ANSWER Stop sodium influx

Stop Calcium influx

Promote potassium efflux

Antagonize glutamate

Potentiate Gamma-Aminobutyric Acid



Common adverse effects if Phenytoin (Dilantin) level >20mcg/mL include: - ANSWER Nystagmus

Sedation

Ataxia (staggering gait)

Diplopia (double vision)

Cognitive impairment



Common side effects of Phenytoin (Dilantin) - ANSWER Sedation and other CNS effects, nystagmus
(>20)

Gingival hyperplasia (oral hygiene & folic acid)

Morbilliform rash -> advance to SJS or TEN, Hypersensitivity with systemic involvement (DRESS) (X
HLA-B 1502 genetic mutation)

Cardiac dysrhythmias and hypotension (Slow IV injection)

Hirsutism

What is Phenytoin (Dilantin)? - ANSWER An anticonvulsant that is active against partial seizures and
primary generalized tonic-clonic seizures.

A selective sodium inhibitor



Therapeutic level of Phenytoin (Dilantin) - ANSWER 10-20 mcg/mL

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