NAPLEX PRACTICE QUESTIONS AND ANSWERS

NAPLEX REVIEW QUESTIONS AND
ANSWERS


Whattistthetequationtfortcorrectedtphenytoin?t-tans✔✔CP=tmeasuredtserumtphenytoin/
(0.2*albumin)+0.1

Whattistthetprincipletintracellulartcation?t-tans✔✔potassium

PrincipletextracellulartistSodium

HowtmanytmLtintatteaspoon?t-tans✔✔5tmL

howtmanytmLtintattablespoont-tans✔✔15tmL

howtmanytmLtintatcup?t-tans✔✔240tmL

howtmanytmLtintantounce?t-tans✔✔29.6tmL

howtmanytmLtintatpint?t-tans✔✔473tmL

howtmanytmLtintatgallon?t-tans✔✔3785tmL

Howtdotwetcalculatetmolstortmmolstoftatsubstance?t-tans✔✔mol=tg/MW
mmol=tmg/MW

Howtmanytmgtaretintonetgrain?t-tans✔✔65tmg/grain

Howtmanytlbstintatkg?t-tans✔✔2.2lbs/kg

Whattistthetconversiontoftaminophyllinettottheophylline?t-
tans✔✔wetmultiplytthetaminophyllinetbyt0.8ttotgettthetequivalentttheophylline




Whattistthetconversiontofttheophyllinettotaminophylline?t-
tans✔✔dividetthetamounttofttheophyllinetbyt0.8ttotgettthetequivalenttaminophylline




Howtdotwetgettthetratiotstrengthtfromtthetpercenttstrength?t-
tans✔✔ratiotstrength=t100/%tstrength

,Howtdotwetgettthetpercenttstrengthtfromtthetratiotstrength?t-tans✔✔%tstrength=t100/
ratiotstrength

HowtdotwetconverttPPMttotpercenttstrength?t-tans✔✔-PPMttot
%tstrength,tmovetdecimaltleftt4tplaces
-%tstrengthttotPPM,tmovetdecimaltplacetrightt4tplaces

specifictgravityt-tans✔✔SG=tgramstoftsubstance/mL

mEqt-tans✔✔mEq=tmgtxtvalence/MW

Whichtchemicalsthavet2tvalences?t-tans✔✔Calciumtcarbonate
Calciumtchloride
Ferroustsulfate
Magnesiumtsulfate

mOsmol/Lt-tans✔✔mOsmol/L=t[wttoftsubstancet(g/L)/MWt(g/
mole)]txtnumbertoftparticlestxt1000

Equationtfortaniontgap`t-tans✔✔Nat-t(Clt+tBicarbonate)

Howtmuchtelementaltcalciumtistfoundtintcalciumtcarbonatetandtcalciumtcitrate?t-
tans✔✔40%tintcarbonate

20%tintcitrate

HowtmuchtelementaltIrontistintferroustfumarate,tferroustsulfate,tandtferroustgluconate?t-
tans✔✔fumarate:t108tmg

sulfate:t65tmgtoft325mgt(20%)
gluconatet35tmg

Howtistabsolutetneutrophiltcounttcalculated?t-tans✔✔ANC=tWBCtxt[(%segst+t%bands)/
100]

Whattistthetformulattotdeterminetatpatient'sttotaltenergytexpenditure?t-
tans✔✔TEE=tBEEtxtactivitytfactortXtstresstfactor




WhattistthetequationttotfindtpHtoftatweaktacid?t-tans✔✔pHt=tpKat+tlog(salt/acid)

WhattistthetequationttotfindtpHtoftatweaktbase?t-tans✔✔pHt=t(pKwt-tpKb)t+tlog(base/salt)

whattcantwettelltabouttionizationtoftacidstfromtthetpHtandtthetpKa?t-
tans✔✔pHt>tpKatmoretacidtistionized

pHt=tpKationizedtandtunionizedtaretequal
pHt<tpKatmoretacidtistunionized

,Antionizedtdrugtistmoretsolubletbuttcannotteasilytcrosstlipidtmembranestandtvicetversa

HowtaretthetABGtmeasurementstwrittentouttontthetexam?t-tans✔✔pH/pCO2/pO2/HCO3/
O2

WhattaretthetnormaltvaluestfortpH,tHCO3,tandtpCO2?t-tans✔✔pHt=t7.35-7.45
HCO3t=t38-42
pCO2t=t22-28

WhentaddingtcalciumtandtphosphatettotTPNtwhattshouldtbetconsidered?t-tans✔✔-
Usetcalciumtgluconatetovertcalciumtchloridetbecausetittistlesstreactivetandtatlowertratetoftpr
ecipitation.
-Addtphosphatetfirsttthentaddtcalciumtattthetendtoftthetprept
-whentaddedttogethertdon'ttexceedt45tmEq/L

BMIt-tans✔✔weighttintkg/heighttintmeter^2

BSAt-tans✔✔BSAt=tSQRt[weight(kg)txtheightt(cm)/3600]

Howtmanytkcalstaretint10%,t20%,tandt30%tintravenoustfattemulsions?
tHowtmuchtfattistneededtfortTPN?t-tans✔✔10%t=t1.1tkcal/mL

20%t=t2tkcal/mL
30%t=t3tkcal/mL

FattfortTPNt=t9tkcal/gram

HowtmanytkcalstdotaminotacidstandtdextrosetprovidetintTPN?t-tans✔✔Aminotacidst4tkcal/
gram
dextroset3.4tkcal/gram

whattistthetpKa?t-
tans✔✔ThetpKatistthetpHtattwhichthalftthetdrugtist50%tionized.tThististhalftthetneutralizationt

ortequivalencetpoint.tThetneutralizationtortequivalencetpointtistattatmuchthighertpHtandtoccu
rstwhentthetacidthastbeentneutralized.

whattistthetcorrecttcalciumtequation?t-tans✔✔CorrectedtCat=t[(4.0-
albumin)txt0.8]t+tserumtcalcium

Whattistthetequationtfortabsolutetbioavailability?t-tans✔✔F=t100txt(AUCtextravascular/
AUCtintravascular)txt(Dosetintravascular/Dosetextravascular)

Whattistthetequationttotfindtthetvolumetoftdistribution?t-tans✔✔Vdt=tamounttoftdrugtgiven/
concentrationtoftdrugtintplasma

Whattistthetequationtfortclearance?t-tans✔✔Clt=tratetoftelimination/concentration
Clt=tFtxtDose/AUC

, Clt=tDose/AUCt(iftbioavailabilitytist1)

whattistthetequationtforttheteliminationtratetconstant?t-tans✔✔ket=tClearance/
volumetoftdistribution

Howtdotwetfindtthethalf-life?t-tans✔✔t1/2t=t0.693/ke

Howtdotwetdefinetpharmacodynamicstvs.tpharmacokinetics?t-
tans✔✔pharmacodynamics: twhattthetdrugtdoesttotthetbody

Pharmacokinetics:twhattthetbodytdoesttotthetdrug

FormulattotdeterminetpatientstLDLt-tans✔✔LDLt=tTCt-tHDLt-tTG/5

Whattaretglass,twedgwood,tandtporcelaintmortarstusedtfor?t-tans✔✔Glass-
tusedtfortmixingtliquidst(solutions,tsuspensions)tandtoilytortstainingtcompounds

Wedgwood-tusedtfortgrindingtdrytcrystalstandthardtpowders
Porcelain-tusedttotblendtpowderstandtpulverizetgummytconsistencies

WhattistthetMastertFormulationtRecord?t-
tans✔✔recipetthattprovidestalltingredientstandtinstructionstfortpreparingtatcompoundedtpro

duct.tincludestcompoundtname,tstrength,tdosagetform,talltcalculations,tandteverythingtnee
dedttotmaketthetcompound

Whattistthetcompoundingtlog?t-tans✔✔it'stthetlogtbooktoftalltproductstmadetintthetpharmacy

whattistatQAtplan?t-
tans✔✔qualitytassurancetplantthattoutlinestthetstepstandtactionstthattensuretthetmaintenan

cetoftpropertstandardstfortcompoundingtpreparations.
needsttotbetreviewedtandtupdatedtregularly.

ADRtoftcompoundedtproductstwouldtbetrecordedtwhere?t-
tans✔✔Intthetpharmacy'stcompoundingtrecord




Comminutiont-tans✔✔reductiontoftsolidtparticlesttotsmallertsizetbytcrushingtortgrinding
AKA-triturationtandtlevigation

triturationt-tans✔✔grindingtpowderstintotsmallertparticlestwithtmotortandtpestle

levigationt-tans✔✔triturationtwithtliquidttothelptgrindingtprocess.

givetantexampletoftatlubricanttfortnon-steriletdrytcompoundingt-tans✔✔magnesiumtstearate

Whattistthetpurposetoftatsurfactanttintregardttotdrytcompounding?tGivetantexamplet-
tans✔✔neutralizestatstatictchargetwhichtkeepstthetpowdertfromtfloatingtaway

-sodiumtlaureltsulfate