MLT HEMATOLOGY EXAM QUESTIONS
WITH CORRECT ANSWERS UPDATED
ACQUIRED hemophilia A may be the result of which of the following conditions? -
Answer-Anti-factor VIII inhibitor
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Patients with acquired hemophilia A are suffering from a coagulation inhibitor,
specifically against factor VIII. Inherited hemophilia A is caused by a deficiency in factor
VIII. Neither warfarin therapy nor thrombosis complications can cause acquired
hemophilia.
Which two of the following are associated with macrocytic anemia? - Answer-Fish
tapeworm Folic acid deficiency
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Both fish tapeworm and folic acid deficiency may appear as a macrocytic anemias.
Which FAB designation is called the "true" monocytic leukemia and is characterized by
monoblasts, promonocytes, and monocytes? - Answer-FAB M5
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FAB M5 is acute monoblastic leukemia
FAB M1 is acute myeloblastic leukemia without maturation
FAB M3 is acute promyelocytic leukemia
FAB M4 is acute myelomonocytic leukemia
What changes Fibrinogen into Fibrin Monomer: - Answer-Thrombin
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Thrombin converts fibrinogen to fibrin monomers. These polymerize to form a fibrin clot,
which is then covalently crosslinked by activated factor XIII (fibrin-stabilizing factor).
Pappenheimer bodies are usually seen in patients who have: - Answer-splenectomies
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Pappenheimer bodies can be found in patients who have had a splenectomy since the
spleen typically removes these cells from the peripheral blood. Therefore, if the spleen
is no longer present, these cells can be found in peripheral smears.
During the flow cytometry analysis process, cells exiting the flow cell intersect a laser,
and produce what kind of data? - Answer-Intrinsic cell characteristics
Extrinsic cell characteristics
, Forward scatter
Fluorescence
As cells exit the flow cell in single file, they intersect the laser and emit the following
data:
Intrinsic cell characteristics
Size (forward scatter)
Granularity (side scatter)
Extrinsic cell characteristics
Surface Antigens (fluorescence emitted by the MoAb bound to the specific antigens)
The peroxidase stain is useful in differentiating between which cells? - Answer-
lymphocytic and granulocytic cells
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Peroxidase stain is an enzymatic stain based on the principle that peroxidase granules
in some neutrophils and in eosinophils will stain positive. Lymphocytes stain negative
with peroxidase stains.
The diagnostic value of the reticulocyte count in the evaluation of anemia is that it
determines the: - Answer-A. response and potential of the bone marrow
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Reticulocytes counts can help determine how well the bone marrow is responding and
its potential to make new RBCs. For example, an increased retic count could show the
physician that the medication given to a patient to treat his/her anemia is working since
the bone marrow is releasing new, young RBCs (reticulocytes).
What is the corrected white blood cell count if the WBC is 14,460, and there were 47
nucleated red blood cells per 100 white blood cells noted on the differential count? -
Answer-B. 9,837 wbc
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Corrected WBC count = uncorrected WBC count x (100 / NRBCs +100)
Corrected WBC count = 14,460 x (100/147) = 9,837
Which of the following test results are NOT characteristic of disseminated intravascular
coagulation (DIC)? - Answer-B. Negative test for fibrin split products
Feedback
Fibrin split products (FSP) and d-dimers are fragments of protein released from a clot
that has been broken down by fibrinolysis. In DIC, the coagulation cascade is triggered
abnormally, resulting in the coagulation system being overwhelmed with excessive
clotting and fibrinolysis taking place. This process of over clotting and over dissolving
creates increased fibrin split products and d-dimers, the opposite of the choice above.
Decreased fibrinogen levels, decreased platelet count, and prolonged PT tests are all
associated with DIC and the consequences of over clotting and over dissolving.
WITH CORRECT ANSWERS UPDATED
ACQUIRED hemophilia A may be the result of which of the following conditions? -
Answer-Anti-factor VIII inhibitor
Feedback
Patients with acquired hemophilia A are suffering from a coagulation inhibitor,
specifically against factor VIII. Inherited hemophilia A is caused by a deficiency in factor
VIII. Neither warfarin therapy nor thrombosis complications can cause acquired
hemophilia.
Which two of the following are associated with macrocytic anemia? - Answer-Fish
tapeworm Folic acid deficiency
Feedback
Both fish tapeworm and folic acid deficiency may appear as a macrocytic anemias.
Which FAB designation is called the "true" monocytic leukemia and is characterized by
monoblasts, promonocytes, and monocytes? - Answer-FAB M5
Feedback
FAB M5 is acute monoblastic leukemia
FAB M1 is acute myeloblastic leukemia without maturation
FAB M3 is acute promyelocytic leukemia
FAB M4 is acute myelomonocytic leukemia
What changes Fibrinogen into Fibrin Monomer: - Answer-Thrombin
Feedback
Thrombin converts fibrinogen to fibrin monomers. These polymerize to form a fibrin clot,
which is then covalently crosslinked by activated factor XIII (fibrin-stabilizing factor).
Pappenheimer bodies are usually seen in patients who have: - Answer-splenectomies
Feedback
Pappenheimer bodies can be found in patients who have had a splenectomy since the
spleen typically removes these cells from the peripheral blood. Therefore, if the spleen
is no longer present, these cells can be found in peripheral smears.
During the flow cytometry analysis process, cells exiting the flow cell intersect a laser,
and produce what kind of data? - Answer-Intrinsic cell characteristics
Extrinsic cell characteristics
, Forward scatter
Fluorescence
As cells exit the flow cell in single file, they intersect the laser and emit the following
data:
Intrinsic cell characteristics
Size (forward scatter)
Granularity (side scatter)
Extrinsic cell characteristics
Surface Antigens (fluorescence emitted by the MoAb bound to the specific antigens)
The peroxidase stain is useful in differentiating between which cells? - Answer-
lymphocytic and granulocytic cells
Feedback
Peroxidase stain is an enzymatic stain based on the principle that peroxidase granules
in some neutrophils and in eosinophils will stain positive. Lymphocytes stain negative
with peroxidase stains.
The diagnostic value of the reticulocyte count in the evaluation of anemia is that it
determines the: - Answer-A. response and potential of the bone marrow
Feedback
Reticulocytes counts can help determine how well the bone marrow is responding and
its potential to make new RBCs. For example, an increased retic count could show the
physician that the medication given to a patient to treat his/her anemia is working since
the bone marrow is releasing new, young RBCs (reticulocytes).
What is the corrected white blood cell count if the WBC is 14,460, and there were 47
nucleated red blood cells per 100 white blood cells noted on the differential count? -
Answer-B. 9,837 wbc
Feedback
Corrected WBC count = uncorrected WBC count x (100 / NRBCs +100)
Corrected WBC count = 14,460 x (100/147) = 9,837
Which of the following test results are NOT characteristic of disseminated intravascular
coagulation (DIC)? - Answer-B. Negative test for fibrin split products
Feedback
Fibrin split products (FSP) and d-dimers are fragments of protein released from a clot
that has been broken down by fibrinolysis. In DIC, the coagulation cascade is triggered
abnormally, resulting in the coagulation system being overwhelmed with excessive
clotting and fibrinolysis taking place. This process of over clotting and over dissolving
creates increased fibrin split products and d-dimers, the opposite of the choice above.
Decreased fibrinogen levels, decreased platelet count, and prolonged PT tests are all
associated with DIC and the consequences of over clotting and over dissolving.
