BIOD322
Diseases of the Nervous System
FINAL ASSESSMENT GUIDE
© Portage 2024/2025
, 1. Which of the following is the hallmark pathological feature of
Alzheimer’s disease?
a) Lewy bodies
b) Pick bodies
c) Neurofibrillary tangles and amyloid plaques
d) Substantia nigra degeneration
Answer: c) Neurofibrillary tangles and amyloid plaques
Rationale: Alzheimer’s disease is characterized by the presence of
neurofibrillary tangles and amyloid plaques in the brain.
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© Portage 2024/2025
, 2. In Multiple Sclerosis (MS), what cellular component is
primarily targeted by the immune system?
a) Neuronal cell bodies
b) Dendrites
c) Axon hillocks
d) Myelin sheath
Answer: d) Myelin sheath
Rationale: MS involves the immune-mediated destruction of the
myelin sheath surrounding axons in the central nervous system.
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3. Which neurotransmitter is most closely associated with the
pathophysiology of Parkinson’s disease?
© Portage 2024/2025
, a) Glutamate
b) Dopamine
c) Serotonin
d) GABA
Answer: b) Dopamine
Rationale: Parkinson’s disease is characterized by the degeneration
of dopaminergic neurons in the substantia nigra, leading to reduced
dopamine levels.
---
4. Guillain-Barré syndrome typically follows which of the
following conditions?
a) Viral infection
© Portage 2024/2025
Diseases of the Nervous System
FINAL ASSESSMENT GUIDE
© Portage 2024/2025
, 1. Which of the following is the hallmark pathological feature of
Alzheimer’s disease?
a) Lewy bodies
b) Pick bodies
c) Neurofibrillary tangles and amyloid plaques
d) Substantia nigra degeneration
Answer: c) Neurofibrillary tangles and amyloid plaques
Rationale: Alzheimer’s disease is characterized by the presence of
neurofibrillary tangles and amyloid plaques in the brain.
---
© Portage 2024/2025
, 2. In Multiple Sclerosis (MS), what cellular component is
primarily targeted by the immune system?
a) Neuronal cell bodies
b) Dendrites
c) Axon hillocks
d) Myelin sheath
Answer: d) Myelin sheath
Rationale: MS involves the immune-mediated destruction of the
myelin sheath surrounding axons in the central nervous system.
---
3. Which neurotransmitter is most closely associated with the
pathophysiology of Parkinson’s disease?
© Portage 2024/2025
, a) Glutamate
b) Dopamine
c) Serotonin
d) GABA
Answer: b) Dopamine
Rationale: Parkinson’s disease is characterized by the degeneration
of dopaminergic neurons in the substantia nigra, leading to reduced
dopamine levels.
---
4. Guillain-Barré syndrome typically follows which of the
following conditions?
a) Viral infection
© Portage 2024/2025
