NUR 2407 EXAM 1 / NUR2407 EXAM 1 ( LATEST ): PHARMACOLOGY
r r r r r r r r r r r
Pharmacokineticsr-rrcorrectranswer--
WHatrtherbodyrdoesrtortherdrug;rabsorption,rdistribution,rmetabolism,rexcretion
Pharmacodynamicsr-rrcorrectranswer--thereffectrtherdrugrhasronrtherbody
Labsrusedrtordeterminerrenalrfunctionr-rrcorrectranswer--BUN,rcreatinine,rGFR
Labsrusedrtordeterminerhepaticrfunctionr-rrcorrectranswer--ALTrandrAST
First-Passreffectr-rrcorrectranswer--
therphenomenonrwherertherconcentrationrofrardrugrisrgreatlyrreducedrbeforeritrreachesrthersystemicrcircul
ationrduertorliverrabsorption
Half-Lifer-rrcorrectranswer--thertimerrequiredrforrtherquantityrofranritemrtorreachrhalfrofritsrinitialrvalue
Tolerancer-rrcorrectranswer--decreasedrresponsivenessrtorardrugroverrthercourserofrtherapy
Blood-Brainrbarrierr-rrcorrectranswer--highlyrselectiversemi-
permiablermembrancerthatrseperatesrcirculatingrbloodrfromrtherbrain'srextra-cellularrfluid
Howrmanyrschedulesrofrcontrolledrsubstancesrarerthere?r-rrcorrectranswer--5
Scheduler1r-rrcorrectranswer--highrpotentialrforrabuse,rnormedicallyracceptableruses
Scheduler2r-rrcorrectranswer--highrpotentialrforrabuserbutrhasrmedicallyracceptedruses:ropioids,rstimulants
Scheduler3r-rrcorrectranswer--
medicallyracceptable,rpotentialrforrabuserisrlessrthanrscheduler1rorr2,rmayrcausersomerdependance
, Scheduler4r-rrcorrectranswer--
medicallyracceptable,rmayrcauserdependance:rphenobarbital,rbenzodiazepines
Whichrschedulercannotrberrefilledr-rrcorrectranswer--scheduler2
Chemicalrnamer-rrcorrectranswer--therdrug'srchemicalrstructure
Genericrnamer-rrcorrectranswer--nonrproprietaryrnamerforrardrug
BrandrNamer-rrcorrectranswer--thertrademarkedrproprietaryrnamerofrardrug
PregnancyrCategoryrAr-rrcorrectranswer--lowrrisk,rnorknownrriskrtorwomenrorrfetus
PregnancyrCategoryrBr-rrcorrectranswer--Animalrstudiesrshowrnorrisk,rnorhumanrtrialrperformed
PregnancyrCategoryrCr-rrcorrectranswer--Animalrstudiesrshowrriskrtorfetus,rnorhumanrtrialrperformed
PregnancyrCategoryrDr-rrcorrectranswer--Harmrtorfetusrisrknown
PregnancyrCategoryrXr-rrcorrectranswer--knownrtorberharmfulrtormotherrandrfetus,rcontraindicated
Additiverdrugreffectr-rrcorrectranswer--1+1=2rthersumrofrthereffectsrofrthertwordrugs
Synergisticrdrugreffectr-rrcorrectranswer--1+1=3,rsumrisrgreaterrthanrindividualrdrugreffectsrparts
Antagonisticrdrugreffectr-rrcorrectranswer--
1+1=1,rtwororrmorerdrugsrinrcombinationrhamperrorreliminaterthereffectrofrtherother
r r r r r r r r r r r
Pharmacokineticsr-rrcorrectranswer--
WHatrtherbodyrdoesrtortherdrug;rabsorption,rdistribution,rmetabolism,rexcretion
Pharmacodynamicsr-rrcorrectranswer--thereffectrtherdrugrhasronrtherbody
Labsrusedrtordeterminerrenalrfunctionr-rrcorrectranswer--BUN,rcreatinine,rGFR
Labsrusedrtordeterminerhepaticrfunctionr-rrcorrectranswer--ALTrandrAST
First-Passreffectr-rrcorrectranswer--
therphenomenonrwherertherconcentrationrofrardrugrisrgreatlyrreducedrbeforeritrreachesrthersystemicrcircul
ationrduertorliverrabsorption
Half-Lifer-rrcorrectranswer--thertimerrequiredrforrtherquantityrofranritemrtorreachrhalfrofritsrinitialrvalue
Tolerancer-rrcorrectranswer--decreasedrresponsivenessrtorardrugroverrthercourserofrtherapy
Blood-Brainrbarrierr-rrcorrectranswer--highlyrselectiversemi-
permiablermembrancerthatrseperatesrcirculatingrbloodrfromrtherbrain'srextra-cellularrfluid
Howrmanyrschedulesrofrcontrolledrsubstancesrarerthere?r-rrcorrectranswer--5
Scheduler1r-rrcorrectranswer--highrpotentialrforrabuse,rnormedicallyracceptableruses
Scheduler2r-rrcorrectranswer--highrpotentialrforrabuserbutrhasrmedicallyracceptedruses:ropioids,rstimulants
Scheduler3r-rrcorrectranswer--
medicallyracceptable,rpotentialrforrabuserisrlessrthanrscheduler1rorr2,rmayrcausersomerdependance
, Scheduler4r-rrcorrectranswer--
medicallyracceptable,rmayrcauserdependance:rphenobarbital,rbenzodiazepines
Whichrschedulercannotrberrefilledr-rrcorrectranswer--scheduler2
Chemicalrnamer-rrcorrectranswer--therdrug'srchemicalrstructure
Genericrnamer-rrcorrectranswer--nonrproprietaryrnamerforrardrug
BrandrNamer-rrcorrectranswer--thertrademarkedrproprietaryrnamerofrardrug
PregnancyrCategoryrAr-rrcorrectranswer--lowrrisk,rnorknownrriskrtorwomenrorrfetus
PregnancyrCategoryrBr-rrcorrectranswer--Animalrstudiesrshowrnorrisk,rnorhumanrtrialrperformed
PregnancyrCategoryrCr-rrcorrectranswer--Animalrstudiesrshowrriskrtorfetus,rnorhumanrtrialrperformed
PregnancyrCategoryrDr-rrcorrectranswer--Harmrtorfetusrisrknown
PregnancyrCategoryrXr-rrcorrectranswer--knownrtorberharmfulrtormotherrandrfetus,rcontraindicated
Additiverdrugreffectr-rrcorrectranswer--1+1=2rthersumrofrthereffectsrofrthertwordrugs
Synergisticrdrugreffectr-rrcorrectranswer--1+1=3,rsumrisrgreaterrthanrindividualrdrugreffectsrparts
Antagonisticrdrugreffectr-rrcorrectranswer--
1+1=1,rtwororrmorerdrugsrinrcombinationrhamperrorreliminaterthereffectrofrtherother
