ATI Pharmacology CH. 1 Exam
Questions & Answers Scored A+
Sublingual and buccal absorption - CORRECT ANSWER-Quick absorption systemically
through highly vascular mucous membranes.
Rectal and vagina absorption - CORRECT ANSWER-Easy absorption with both local
and systemic effects
Absorption with Inhalation via mouth, nose. - CORRECT ANSWER-Rapid absorption
through alveolar capillary networks
Intradermal, topical absorption - CORRECT ANSWER-Slow, gradual absorption.
Effects primarily, but systemic as well, especially with lipid-soluble medications passing
through subcutaneous fatty tissue.
Subcutaneous, Intramuscular absorption - CORRECT ANSWER-Solubility of the
medication in water:
-Highly soluble medications have rapid absorption (10 to 30 min)
-Poorly soluble medications have slow absorption.
Blood perfusion at the site of injection:
-Sites with high blood perfusion have rapid absorption
-Sites with low blood perfusion have slow absorption.
Intravenous absorption - CORRECT ANSWER-Immediate: enters directly into the blood
Complete: Reaches the blood in its entirety
, What are barriers to intravenous absorption? - CORRECT ANSWER-There are no
barriers.
What are the barriers to subcutaneous and intramuscular absorption? - CORRECT
ANSWER-Capillary walls have large spaces between the cells. Therefore, there is no
significant barrier.
What are barriers to intradermal, and topical absorption? - CORRECT ANSWER-Close
proximity of epidermal cells.
What are barriers to inhalation? - CORRECT ANSWER-Inspiratory effect
What are the factors influencing distribution? - CORRECT ANSWER-Circulation,
permeability of the cell membrane, plasma protein binding,
Where does excretion take place? - CORRECT ANSWER-The kidneys. Elimination also
takes place through the liver, lungs, intestines, and exocrine glands (such as breastmilk)
Kidney dysfunction can lead to what? What is important to monitor? - CORRECT
ANSWER-It can lead to an increase in the duration and intensity of a medications
response, so it is important to monitor BUM and creatinine levels.
Therapeutic index (TI) - CORRECT ANSWER-High level: have a wide safety margin so
there is no need for routine serum medication-level monitoring.
Low: Require close monitoring of the serum medication levels.
Half-life - CORRECT ANSWER-Liver and Kidney function affect Half-life.
It usually takes 4 half-lives to achieve a steady state of serum concentration (medication
intake=Medication metabolism and excretion.)
MEC - CORRECT ANSWER-Minimum effective concentration
Questions & Answers Scored A+
Sublingual and buccal absorption - CORRECT ANSWER-Quick absorption systemically
through highly vascular mucous membranes.
Rectal and vagina absorption - CORRECT ANSWER-Easy absorption with both local
and systemic effects
Absorption with Inhalation via mouth, nose. - CORRECT ANSWER-Rapid absorption
through alveolar capillary networks
Intradermal, topical absorption - CORRECT ANSWER-Slow, gradual absorption.
Effects primarily, but systemic as well, especially with lipid-soluble medications passing
through subcutaneous fatty tissue.
Subcutaneous, Intramuscular absorption - CORRECT ANSWER-Solubility of the
medication in water:
-Highly soluble medications have rapid absorption (10 to 30 min)
-Poorly soluble medications have slow absorption.
Blood perfusion at the site of injection:
-Sites with high blood perfusion have rapid absorption
-Sites with low blood perfusion have slow absorption.
Intravenous absorption - CORRECT ANSWER-Immediate: enters directly into the blood
Complete: Reaches the blood in its entirety
, What are barriers to intravenous absorption? - CORRECT ANSWER-There are no
barriers.
What are the barriers to subcutaneous and intramuscular absorption? - CORRECT
ANSWER-Capillary walls have large spaces between the cells. Therefore, there is no
significant barrier.
What are barriers to intradermal, and topical absorption? - CORRECT ANSWER-Close
proximity of epidermal cells.
What are barriers to inhalation? - CORRECT ANSWER-Inspiratory effect
What are the factors influencing distribution? - CORRECT ANSWER-Circulation,
permeability of the cell membrane, plasma protein binding,
Where does excretion take place? - CORRECT ANSWER-The kidneys. Elimination also
takes place through the liver, lungs, intestines, and exocrine glands (such as breastmilk)
Kidney dysfunction can lead to what? What is important to monitor? - CORRECT
ANSWER-It can lead to an increase in the duration and intensity of a medications
response, so it is important to monitor BUM and creatinine levels.
Therapeutic index (TI) - CORRECT ANSWER-High level: have a wide safety margin so
there is no need for routine serum medication-level monitoring.
Low: Require close monitoring of the serum medication levels.
Half-life - CORRECT ANSWER-Liver and Kidney function affect Half-life.
It usually takes 4 half-lives to achieve a steady state of serum concentration (medication
intake=Medication metabolism and excretion.)
MEC - CORRECT ANSWER-Minimum effective concentration
