Antidepressants
Possible Indications: Depression, Eating disorder, Pain disorder, Enuresis, OCD, GAD, PTSD, Paraphilias, PMS,
Smoking cessation.
Therapeutic effects: Mood: Reduce sadness, irritability, and anhedonia.
Thoughts: Reduce hopelessness, pessimism, guilt, and suicidal thoughts, improve concentration and memory.
Behavior: Improve diminish libido; reduce somatic complaints; improve energy and appetite
Sleep: Improve sleep disturbance (insomnia, early morning awakening, hypersomnia)
Onset: All antidepressant may take as long as 6 weeks to achieve therapeutic effect and may take longer for
maximum benefit.
Monoamine Oxidase Inhibitors (MAOI)
Generic Brand Dose Half-life
Tranylcypromine Parnate® 10 – 60 mg/d unknown
Phenelzine Nardil® 7.5 – 90 mg/d unknown
Isocarboxazid Marplan® 10 – 60 mg/d unknown
* Selegiline Transdermal * Emsam® 6 mg – 9 mg/24 hr 16 – 69 hours
System
Tyramine is an amino acid released from proteins during aging, fermenting, pickling, smoking, and spoiling. In the
body, tyramine triggers the release of norepinephrine from adrenergic nerve endings and is then deactivated by
monoamine oxidase (MAO) in the liver and intestine. However, in a patient taking a MAO inhibitor, tyramine levels
may increase and cause large amounts of norepinephrine to be released, which could lead to a hypertensive reaction
and intracranial bleed.
Aged Cheeses Blue Gouda Romano
Camembert Parmesan Stilton
Cheddar Provolone Swiss
Alcoholic Beverages Beer Liqueurs Sherry
Cognac Red Wine
Fish Caviar Fermented, aged Smoked
Shrimp paste cured or dried Pickled
Fruits Bananas Raisins
Fig Prunes
Meats Beef or chicken liver Smoked and processed meats
Corned beef (such as bologna, pepperoni, salami)
Vegetables Avocados Fermented bean curd Sauerkraut
Chinese pea pods Olives Pickles
Fava beans Flat Italian Beans Soybean paste
Other Sources Beverages containing caffeine Monosodium Glutamate
Cheese-filled desserts Protein supplements
Medications Pseudoepherine TCA
Dextromethrophan SSRI
Tricyclic Antidepressants (TCA)
Possible Indications: Depression, Eating disorder, Pain disorder, Enuresis, OCD, GAD, PTSD, Paraphilias, PMS,
Smoking cessation.
Therapeutic effects: Mood: Reduce sadness, irritability, and anhedonia.
Thoughts: Reduce hopelessness, pessimism, guilt, and suicidal thoughts, improve concentration and memory.
Behavior: Improve diminish libido; reduce somatic complaints; improve energy and appetite
Sleep: Improve sleep disturbance (insomnia, early morning awakening, hypersomnia)
Onset: All antidepressant may take as long as 6 weeks to achieve therapeutic effect and may take longer for
maximum benefit.
Monoamine Oxidase Inhibitors (MAOI)
Generic Brand Dose Half-life
Tranylcypromine Parnate® 10 – 60 mg/d unknown
Phenelzine Nardil® 7.5 – 90 mg/d unknown
Isocarboxazid Marplan® 10 – 60 mg/d unknown
* Selegiline Transdermal * Emsam® 6 mg – 9 mg/24 hr 16 – 69 hours
System
Tyramine is an amino acid released from proteins during aging, fermenting, pickling, smoking, and spoiling. In the
body, tyramine triggers the release of norepinephrine from adrenergic nerve endings and is then deactivated by
monoamine oxidase (MAO) in the liver and intestine. However, in a patient taking a MAO inhibitor, tyramine levels
may increase and cause large amounts of norepinephrine to be released, which could lead to a hypertensive reaction
and intracranial bleed.
Aged Cheeses Blue Gouda Romano
Camembert Parmesan Stilton
Cheddar Provolone Swiss
Alcoholic Beverages Beer Liqueurs Sherry
Cognac Red Wine
Fish Caviar Fermented, aged Smoked
Shrimp paste cured or dried Pickled
Fruits Bananas Raisins
Fig Prunes
Meats Beef or chicken liver Smoked and processed meats
Corned beef (such as bologna, pepperoni, salami)
Vegetables Avocados Fermented bean curd Sauerkraut
Chinese pea pods Olives Pickles
Fava beans Flat Italian Beans Soybean paste
Other Sources Beverages containing caffeine Monosodium Glutamate
Cheese-filled desserts Protein supplements
Medications Pseudoepherine TCA
Dextromethrophan SSRI
Tricyclic Antidepressants (TCA)
