Veterinary Pharmacology
Final Exam Questions
and Complete Solutions
Graded A+
Denning [Date] [Course title]
,Phospholipase - Answer: Phospholipids are made into arachidonic acid by what enzymes?
Cyclooxygenase - Answer: Arachidonic acid is made into PGG2 by what enzyme?
Anti-inflammatory, analgesic and antipyretic - Answer: What are the 3 pharmacological effects of
NSAIDs?
Anti-inflammatory - Answer: What pharmacological effects of NSAIDs?
- modifications of inflammatory reactions
- decrease in inflammatory prostaglandin production
Analgesic - Answer: What pharmacological effects of NSAIDs?
- reduction of pain
Antipyretic - Answer: What pharmacological effects of NSAIDs?
- lowering of raised temperature
- partly due to decreased release of prostaglandins in response to interleukin-1 (IL-1)
TXA2 - Answer: The antithrombotic effect is a side effect of NSAIDs because they inhibit ____ synthesis
False (causes stomach ulcers and internal bleeding) - Answer: True/False
Concurrent use of corticosteroids and NSAIDs should be avoided due to increased risk of renal failure?
COX2 - Answer: Which COX is the inducible form? Also it synthesizes prostaglandins responsible for
inflammation and pain
COX1 - Answer: Which COX is the basal form? Also it synthesizes prostaglandins for maintenance and
protection of the GI tract
, Aspirin - Answer: ____ anti-inflammatory Mechanism, permanently inactivates prostaglandin synthase
until it is replaced by new synthesis, granulocytes (neutrophils, eosinophils, mast cells, and basophils)
also effected
Rimadyl (Carprofen) - Answer: - World's most frequently prescribed canine NSAID
- Indicated for the relief of pain and inflammation associated with osteoarthritis in dogs
- Received approval for controlling post operative pain associated with soft tissue and orthopedic
surgery in dogs
- Lower incidence of GI disturbance
False (NEVER) - Answer: True/False
You can sometimes administer cats Carprofen (Rimadyl) for OA
injectable - Answer: The ____ form of Rimadyl is indicated for the control of pain and inflammation
associated with osteoarthritis and both soft tissue and orthopedic surgeries
phenobarbital - Answer: Concurrent use of carprofen and ____ can alter the activity of one or both
drugs
Zubrin (Tepoxalin) - Answer: ___ mechanism of action is inhibition of cyclooxygenase activity and
lipoxygenase and is thus classified as a dual inhibitor of arachidonic acid metabolism
True - Answer: True/False
Zubrin is not approved in cats
leukotrienes - Answer: By using Zubrin in dogs you are inhibiting lipoxygenase which is used to
produced inflammatory _____
Previcox (firocoxib) - Answer: - Approved to treat pain and inflammation in dogs suffering from
osteoarthritis and reported to have 24-hour therapeutic pain relief
- selectively inhibit COX-2 cyclooxygenase activity
Final Exam Questions
and Complete Solutions
Graded A+
Denning [Date] [Course title]
,Phospholipase - Answer: Phospholipids are made into arachidonic acid by what enzymes?
Cyclooxygenase - Answer: Arachidonic acid is made into PGG2 by what enzyme?
Anti-inflammatory, analgesic and antipyretic - Answer: What are the 3 pharmacological effects of
NSAIDs?
Anti-inflammatory - Answer: What pharmacological effects of NSAIDs?
- modifications of inflammatory reactions
- decrease in inflammatory prostaglandin production
Analgesic - Answer: What pharmacological effects of NSAIDs?
- reduction of pain
Antipyretic - Answer: What pharmacological effects of NSAIDs?
- lowering of raised temperature
- partly due to decreased release of prostaglandins in response to interleukin-1 (IL-1)
TXA2 - Answer: The antithrombotic effect is a side effect of NSAIDs because they inhibit ____ synthesis
False (causes stomach ulcers and internal bleeding) - Answer: True/False
Concurrent use of corticosteroids and NSAIDs should be avoided due to increased risk of renal failure?
COX2 - Answer: Which COX is the inducible form? Also it synthesizes prostaglandins responsible for
inflammation and pain
COX1 - Answer: Which COX is the basal form? Also it synthesizes prostaglandins for maintenance and
protection of the GI tract
, Aspirin - Answer: ____ anti-inflammatory Mechanism, permanently inactivates prostaglandin synthase
until it is replaced by new synthesis, granulocytes (neutrophils, eosinophils, mast cells, and basophils)
also effected
Rimadyl (Carprofen) - Answer: - World's most frequently prescribed canine NSAID
- Indicated for the relief of pain and inflammation associated with osteoarthritis in dogs
- Received approval for controlling post operative pain associated with soft tissue and orthopedic
surgery in dogs
- Lower incidence of GI disturbance
False (NEVER) - Answer: True/False
You can sometimes administer cats Carprofen (Rimadyl) for OA
injectable - Answer: The ____ form of Rimadyl is indicated for the control of pain and inflammation
associated with osteoarthritis and both soft tissue and orthopedic surgeries
phenobarbital - Answer: Concurrent use of carprofen and ____ can alter the activity of one or both
drugs
Zubrin (Tepoxalin) - Answer: ___ mechanism of action is inhibition of cyclooxygenase activity and
lipoxygenase and is thus classified as a dual inhibitor of arachidonic acid metabolism
True - Answer: True/False
Zubrin is not approved in cats
leukotrienes - Answer: By using Zubrin in dogs you are inhibiting lipoxygenase which is used to
produced inflammatory _____
Previcox (firocoxib) - Answer: - Approved to treat pain and inflammation in dogs suffering from
osteoarthritis and reported to have 24-hour therapeutic pain relief
- selectively inhibit COX-2 cyclooxygenase activity
