MCB4203 Antibiotics Exam Study Guide

MCB4203 Antibiotics Exam Study
Guide
mechanism:

β-lactams (penicillins, cephalosporins, carbapenems, monobactams) - Answer Inhibit
transpeptidation step in peptidoglycan synthesis; bind penicillin-binding proteins;
stimulate autolysins

mechanism:

Glycopeptides - Answer Inhibit transglycosylation and transpeptidation steps in
peptidoglycan synthesis by binding D-ala-D-ala

mechanism:

Tetracyclines - Answer Bind 16S rRNA in 30S subunit of bacterial ribosome; disrupt
bacterial membrane

mechanism:

Macrolides/lincosamides - Answer Bind 23S rRNA in 50S subunit of bacterial ribosome

mechanism:

Streptogramins - Answer Bind 23S rRNA in 50S subunit of bacterial ribosome

mechanism:

Fluoroquinolones - Answer Bind DNA gyrase

mechanism:

Rifampim - Answer Binds β-subunit of bacterial RNA polymerase

resistance mechanisms:

β-lactams (penicillins, cephalosporins, carbapenems, monobactams) - Answer Gram -
outer membrane; porin mutations; β-lactamase; modify target (alteration of
penicillin-binding protein)

resistance mechanisms:

Glycopeptides - Answer Gram - outer membrane; modify target (substitute
D-ala-D-lactate for D-ala-D-ala)

resistance mechanisms:

Tetracyclines - Answer Inactivation of antibiotic (?); ribosome protection; efflux system