MCB4203 EXAM 3 STUDY GUIDE
Which one of these secretion systems is used by Mycobacterium and it is also important
in virulence? - Answer Type Seven Secretion System
Do Type Two secretion systems use one-, two-, or three-step process of protein
secretion? - Answer It is a two-step process, where Sec or Tat mechanisms are involved
as well as translocation via the outer membrane
Which statement is true about Type Four Secretion System? - Answer It is an apparatus
composed of several proteins, which can be used to deliver genetic material and
virulence factors by pathogens
Where is the pore of Type Three Secretion System inserted during the infection process
to accomplish the secretion of virulence factors into the host cell? - Answer In the cell
membrane of a host cell
In the two-component system, which molecule becomes phosphorylated on the Aspartic
acid residue? - Answer Response regulator
What molecule do the autoinducer oligopeptides bind to in order to have a function in
the regulation of the downstream gene expression? - Answer Sensor kinase
Which group of bacteria primarily uses hydrophobic autoinducers that bind to the
response regulator in the cell? - Answer Gram-negative bacteria
Which of the following is an example of a bacterial factor that has been shown to
promote the development and spread of drug-resistance in bacteria? - Answer Inter-
and intra-species horizontal gene transfer of bacterial antibiotic resistance genes
What is the antibiotic efflux mechanism adapted by some bacteria?
Group of answer choices - Answer Transport of antibiotic outside of the bacterial cell
What are penicillin-binding proteins? - Answer Bacterial proteins that bind b-lactam and
b-lactams inactivate PBPs
OR
Bacterial proteins that bind b-lactam and inactivate it
Which of the following is NOT an example of a disinfectant:
Alcohols
Tetracycline
Quaternary Ammonium Cations (QACs)
Phenol
, Halide - Answer Tetracycline
Bactericidal agent - Answer Agent that leads to a killing of bacteria
Bacteriostatic agent - Answer Agent that leads to an inhibition of bacterial growth
What type of antibiotic is Erythromycin? - Answer Macrolide
What antibiotic are the ESBLs resistant to? - Answer A wide range of beta lactam
ring-containing antibiotics
What is the key difference between the antiporters and ABC transporters as efflux
pumps? - Answer Antiporters are fueled by the uptake of protons while ABC
transporters are fueled by ATP hydrolysis
What is the function of TetR in the regulation of Tetracycline resistance? - Answer The
repression of tetB expression when there is no tetracycline present
What is the current recommended antibiotic treatment for gonorrhea (GC) based on the
AMR acquired by the bacterium that causes this disease? - Answer Ceftriaxone and
azithromycin
Which pathogen is coagulase-negative Staphylococcus? - Answer S. epidermidis
Which licensed vaccine that prevents S. pneumoniae would be the best one to use in
infants? - Answer PCV-7 conjugated vacine
Which of the following is NOT a disease typically associated with S. pneumoniae?
Bacterial meningitis
Pneumonia
Catheter infection
Ear infection (otitis) - Answer Catheter infection
Unencapsulated strains of S. pneumoniae have an increased capacity to form biofilms.
True or false? - Answer True
Which component of S. epidermidis is important for the maintenance of the homeostasis
following the osmolarity changes? - Answer Sodium ion / proton pump
S. aureus methicillin‐resistance is encoded by the mecA gene, the product of which ___ -
Answer encodes an alternative penicillin-binding protein that is no longer recognized by
methicillin and related antibiotics.
Which one is the most predominant strain of community-acquired MRSA? - Answer
USA300 strain
What is the function of Pyocyanin? - Answer This pigment interferes with redox cycle in
Which one of these secretion systems is used by Mycobacterium and it is also important
in virulence? - Answer Type Seven Secretion System
Do Type Two secretion systems use one-, two-, or three-step process of protein
secretion? - Answer It is a two-step process, where Sec or Tat mechanisms are involved
as well as translocation via the outer membrane
Which statement is true about Type Four Secretion System? - Answer It is an apparatus
composed of several proteins, which can be used to deliver genetic material and
virulence factors by pathogens
Where is the pore of Type Three Secretion System inserted during the infection process
to accomplish the secretion of virulence factors into the host cell? - Answer In the cell
membrane of a host cell
In the two-component system, which molecule becomes phosphorylated on the Aspartic
acid residue? - Answer Response regulator
What molecule do the autoinducer oligopeptides bind to in order to have a function in
the regulation of the downstream gene expression? - Answer Sensor kinase
Which group of bacteria primarily uses hydrophobic autoinducers that bind to the
response regulator in the cell? - Answer Gram-negative bacteria
Which of the following is an example of a bacterial factor that has been shown to
promote the development and spread of drug-resistance in bacteria? - Answer Inter-
and intra-species horizontal gene transfer of bacterial antibiotic resistance genes
What is the antibiotic efflux mechanism adapted by some bacteria?
Group of answer choices - Answer Transport of antibiotic outside of the bacterial cell
What are penicillin-binding proteins? - Answer Bacterial proteins that bind b-lactam and
b-lactams inactivate PBPs
OR
Bacterial proteins that bind b-lactam and inactivate it
Which of the following is NOT an example of a disinfectant:
Alcohols
Tetracycline
Quaternary Ammonium Cations (QACs)
Phenol
, Halide - Answer Tetracycline
Bactericidal agent - Answer Agent that leads to a killing of bacteria
Bacteriostatic agent - Answer Agent that leads to an inhibition of bacterial growth
What type of antibiotic is Erythromycin? - Answer Macrolide
What antibiotic are the ESBLs resistant to? - Answer A wide range of beta lactam
ring-containing antibiotics
What is the key difference between the antiporters and ABC transporters as efflux
pumps? - Answer Antiporters are fueled by the uptake of protons while ABC
transporters are fueled by ATP hydrolysis
What is the function of TetR in the regulation of Tetracycline resistance? - Answer The
repression of tetB expression when there is no tetracycline present
What is the current recommended antibiotic treatment for gonorrhea (GC) based on the
AMR acquired by the bacterium that causes this disease? - Answer Ceftriaxone and
azithromycin
Which pathogen is coagulase-negative Staphylococcus? - Answer S. epidermidis
Which licensed vaccine that prevents S. pneumoniae would be the best one to use in
infants? - Answer PCV-7 conjugated vacine
Which of the following is NOT a disease typically associated with S. pneumoniae?
Bacterial meningitis
Pneumonia
Catheter infection
Ear infection (otitis) - Answer Catheter infection
Unencapsulated strains of S. pneumoniae have an increased capacity to form biofilms.
True or false? - Answer True
Which component of S. epidermidis is important for the maintenance of the homeostasis
following the osmolarity changes? - Answer Sodium ion / proton pump
S. aureus methicillin‐resistance is encoded by the mecA gene, the product of which ___ -
Answer encodes an alternative penicillin-binding protein that is no longer recognized by
methicillin and related antibiotics.
Which one is the most predominant strain of community-acquired MRSA? - Answer
USA300 strain
What is the function of Pyocyanin? - Answer This pigment interferes with redox cycle in
