Test Bank for Janeway’s Immunobiology, 11th
Edition Kenneth M. Murphy, Casey Weaver
Examples of pathogens that cause human disease include:
a. bacteria
b. viruses
c. fungi
d. parasites (protozoans and worms)
e. All of the above - ANSWER e. All of the above
Which of the following is not associated with mucosal surfaces?
a. mucus-secreting goblet cells
b. lysozyme
c. M cells
d. beating cilia
e. white pulp - ANSWER e. white pulp
One reason that pathogenic microorganisms have an advantage in the host they
infect
is because they:
a. have previously been encountered through natural exposure
b. reproduce and evolve more rapidly than the host can eliminate them.
c. have previously been encountered through vaccination
d. strengthen the host's immune response
e. reproduce and evolve more slowly than the host can eliminate them. - ANSWER
b. reproduce and evolve more rapidly than the host can eliminate them.
Which of the following is not a characteristic of inflammation?
a. increased vascular permeability and edema
b. vasodilation
c. pain
d. inactivation of macrophages
e. influx of leukocytes - ANSWER d. inactivation of macrophages
Which of the following pairs is mismatched?
a. natural killer cell: kills virus-infected cells
b. macrophage: phagocytosis and killing of microorganisms
c. lymphocytes: innate immune response
d. erythrocyte: oxygen transport
e. eosinophil: defense against parasites. - ANSWER c. lymphocytes: innate immune
response
A term generally used to describe all white blood cells is:
a. leukocytes
b. hematopoietic cells
c. myeloid progenitor
,d. dendritic cells
e. monocytes - ANSWER a. leukocytes
Examples of granulocytes include all of the following except:
a. neutrophil
b. basophil
c. eosinophil
d. monocyte
e. All of the above are examples of granulocytes. - ANSWER d. monocyte
The most abundant type of leukocyte in human peripheral blood is:
a. eosinophil
b. basophil
c. monocyte
d. lymphocyte
e. neutrophil - ANSWER e. neutrophil
Which of the following statements is correct?
a. Macrophages are granulocytes.
b. Macrophages are non-phagocytic.
c. Macrophages derive from monocytes.
d. Macrophages do not reside in the tissues.
e. All of the above statements are false. - ANSWER c. Macrophages derive from
monocytes.
Which of the following pairs is mismatched?
a. monocyte progenitor: macrophage
b. erythroid progenitor: megakaryocyte
c. myeloid progenitor: neutrophil
d. lymphoid progenitor: natural killer cell
e. None of the above is mismatched. - ANSWER e. None of the above is
mismatched.
Which of the following pairs of associations is mismatched?
a. megakaryocyte: platelet
b. B cell: plasma cell
c. monocyte: macrophage
d. large granular lymphocyte: T cell
e. myeloid progenitor: neutrophil. - ANSWER d. large granular lymphocyte: T cell
Which of the following statements is false?
a. The hematopoietic stem cell gives rise to white blood cells but a different stem cell
is
the progenitor of red blood cells.
b. During human development, hematopoiesis takes place at different anatomical
locations.
c. Hematopoietic stem cells are self-renewing.
d. Platelets participate in clotting reactions to prevent blood loss.
,e. Megakaryocytes do not circulate and reside only in the bone marrow. - ANSWER
a. The hematopoietic stem cell gives rise to white blood cells but a different stem cell
is
the progenitor of red blood cells.
Which statement below is TRUE regarding the regulation and homeostasis of
hematopoiesis?
a. Transcription factors are extracellular proteins that bind to genes in the nucleus
and
down-regulate (inhibit) their expression. They play important roles in the regulation
of hematopoiesis.
b. Hematopoiesis is a steady-state process: mature blood cells are produced at a
higher
rate at which they are lost.
c. It is the development of white blood cells or leukocytes (e.g., lymphocytes,
neutrophils, basophils, eosinophils, and monocytes) but not red blood cells and
dendritic cells.
d. The development of pluripotent stem cells into different cell types requires the
expression of different sets of lineage-determining and lineage-specific genes, at
appropriate times and in the correct order.
e. All the answers above are true. - ANSWER d. The development of pluripotent
stem cells into different cell types requires the
expression of different sets of lineage-determining and lineage-specific genes, at
appropriate times and in the correct order.
As to human stem cells, which statement below is false?
a. Embryonic stem cells are unipotent, that is, they can only generate the same cell
type
as themselves. In contrast, adult (somatic) stem cells are pluripotent and can give
rise
to most but not all of the cell types.
b. Stem cells are undifferentiated or unspecialized cells that can differentiate into
different cell types.
c. All stem cells, regardless of their source, have three general properties: 1) they
are
capable of dividing and renewing themselves for long periods; 2) they are
unspecialized; and 3) they can give rise to specialized cell types.
d. Embryonic stem cells derived from embryos that develop from eggs that have
been
fertilized in vitro.
e. Adult (or somatic) stem cells are undifferentiated cells found among differentiated
cells in a tissue or organ, and can renew themselves and become the specific cells
of
the tissues they reside. - ANSWER a. Embryonic stem cells are unipotent, that is,
they can only generate the same cell type
as themselves. In contrast, adult (somatic) stem cells are pluripotent and can give
rise
to most but not all of the cell types.
, Secondary lymphoid organs are able to trap antigen, generally from nearby tissues
or
vascular spaces and are sites where mature lymphocytes can interact effectively
with
antigen. The secondary lymphoid organs include:
a. lymph nodes, spleen, and mucosal-associated lymphoid tissues (MALT), and
bone
marrow.
b. lymph nodes, spleen, and mucosal-associated lymphoid tissues (MALT) (e.g.,
tonsils,
appendix, adenoids, Peyer's patches).
c. thymus and bone marrow.
d. lymph nodes, spleen, and thymus.
e. all of the above. - ANSWER b. lymph nodes, spleen, and mucosal-associated
lymphoid tissues (MALT) (e.g., tonsils,
appendix, adenoids, Peyer's patches).
Which of the following describes the flow of lymph through a lymph node draining
an infected tissue?
a. afferent lymphatic vessel lymph node efferent lymphatic vessel
b. efferent lymphatic vessel lymph node afferent lymphatic vessel
c. venule lymph node efferent lymphatic vessel
d. artery lymph node efferent lymphatic vessel
e. afferent lymphatic vessel lymph node artery. - ANSWER a. afferent lymphatic
vessel lymph node efferent lymphatic vessel
Which of the following pairs is mismatched?
a. T-cell activation: cell division and differentiation
b. helper T cell: kills pathogen-infected cells
c. effector B cell: plasma cell
d. plasma cell: antibody secretion
e. helper T cell: facilitates differentiation of B cells. - ANSWER b. helper T cell: kills
pathogen-infected cells
Vaccination is best described as prevention of severe disease by:
a. prior exposure to a pathogen in an attenuated or weakened form, or to an antigen
derived from that pathogen.
b. deliberate introduction of a virulent strain of an infectious agent
c. prophylactic treatment with antibiotics
d. stimulating effective innate immune responses
e. using effective public health isolation regimens such as quarantine. - ANSWER a.
prior exposure to a pathogen in an attenuated or weakened form, or to an antigen
derived from that pathogen.
Which of the following explains why immunity to influenza may appear to be
relatively short-lived?
a. Effective immunological memory fails to develop.
b. Immune responses to influenza involve innate immune mechanisms only.
c. New influenza variants able to escape prior immunity regularly.
d. The primary and secondary immune responses are equivalent.
Edition Kenneth M. Murphy, Casey Weaver
Examples of pathogens that cause human disease include:
a. bacteria
b. viruses
c. fungi
d. parasites (protozoans and worms)
e. All of the above - ANSWER e. All of the above
Which of the following is not associated with mucosal surfaces?
a. mucus-secreting goblet cells
b. lysozyme
c. M cells
d. beating cilia
e. white pulp - ANSWER e. white pulp
One reason that pathogenic microorganisms have an advantage in the host they
infect
is because they:
a. have previously been encountered through natural exposure
b. reproduce and evolve more rapidly than the host can eliminate them.
c. have previously been encountered through vaccination
d. strengthen the host's immune response
e. reproduce and evolve more slowly than the host can eliminate them. - ANSWER
b. reproduce and evolve more rapidly than the host can eliminate them.
Which of the following is not a characteristic of inflammation?
a. increased vascular permeability and edema
b. vasodilation
c. pain
d. inactivation of macrophages
e. influx of leukocytes - ANSWER d. inactivation of macrophages
Which of the following pairs is mismatched?
a. natural killer cell: kills virus-infected cells
b. macrophage: phagocytosis and killing of microorganisms
c. lymphocytes: innate immune response
d. erythrocyte: oxygen transport
e. eosinophil: defense against parasites. - ANSWER c. lymphocytes: innate immune
response
A term generally used to describe all white blood cells is:
a. leukocytes
b. hematopoietic cells
c. myeloid progenitor
,d. dendritic cells
e. monocytes - ANSWER a. leukocytes
Examples of granulocytes include all of the following except:
a. neutrophil
b. basophil
c. eosinophil
d. monocyte
e. All of the above are examples of granulocytes. - ANSWER d. monocyte
The most abundant type of leukocyte in human peripheral blood is:
a. eosinophil
b. basophil
c. monocyte
d. lymphocyte
e. neutrophil - ANSWER e. neutrophil
Which of the following statements is correct?
a. Macrophages are granulocytes.
b. Macrophages are non-phagocytic.
c. Macrophages derive from monocytes.
d. Macrophages do not reside in the tissues.
e. All of the above statements are false. - ANSWER c. Macrophages derive from
monocytes.
Which of the following pairs is mismatched?
a. monocyte progenitor: macrophage
b. erythroid progenitor: megakaryocyte
c. myeloid progenitor: neutrophil
d. lymphoid progenitor: natural killer cell
e. None of the above is mismatched. - ANSWER e. None of the above is
mismatched.
Which of the following pairs of associations is mismatched?
a. megakaryocyte: platelet
b. B cell: plasma cell
c. monocyte: macrophage
d. large granular lymphocyte: T cell
e. myeloid progenitor: neutrophil. - ANSWER d. large granular lymphocyte: T cell
Which of the following statements is false?
a. The hematopoietic stem cell gives rise to white blood cells but a different stem cell
is
the progenitor of red blood cells.
b. During human development, hematopoiesis takes place at different anatomical
locations.
c. Hematopoietic stem cells are self-renewing.
d. Platelets participate in clotting reactions to prevent blood loss.
,e. Megakaryocytes do not circulate and reside only in the bone marrow. - ANSWER
a. The hematopoietic stem cell gives rise to white blood cells but a different stem cell
is
the progenitor of red blood cells.
Which statement below is TRUE regarding the regulation and homeostasis of
hematopoiesis?
a. Transcription factors are extracellular proteins that bind to genes in the nucleus
and
down-regulate (inhibit) their expression. They play important roles in the regulation
of hematopoiesis.
b. Hematopoiesis is a steady-state process: mature blood cells are produced at a
higher
rate at which they are lost.
c. It is the development of white blood cells or leukocytes (e.g., lymphocytes,
neutrophils, basophils, eosinophils, and monocytes) but not red blood cells and
dendritic cells.
d. The development of pluripotent stem cells into different cell types requires the
expression of different sets of lineage-determining and lineage-specific genes, at
appropriate times and in the correct order.
e. All the answers above are true. - ANSWER d. The development of pluripotent
stem cells into different cell types requires the
expression of different sets of lineage-determining and lineage-specific genes, at
appropriate times and in the correct order.
As to human stem cells, which statement below is false?
a. Embryonic stem cells are unipotent, that is, they can only generate the same cell
type
as themselves. In contrast, adult (somatic) stem cells are pluripotent and can give
rise
to most but not all of the cell types.
b. Stem cells are undifferentiated or unspecialized cells that can differentiate into
different cell types.
c. All stem cells, regardless of their source, have three general properties: 1) they
are
capable of dividing and renewing themselves for long periods; 2) they are
unspecialized; and 3) they can give rise to specialized cell types.
d. Embryonic stem cells derived from embryos that develop from eggs that have
been
fertilized in vitro.
e. Adult (or somatic) stem cells are undifferentiated cells found among differentiated
cells in a tissue or organ, and can renew themselves and become the specific cells
of
the tissues they reside. - ANSWER a. Embryonic stem cells are unipotent, that is,
they can only generate the same cell type
as themselves. In contrast, adult (somatic) stem cells are pluripotent and can give
rise
to most but not all of the cell types.
, Secondary lymphoid organs are able to trap antigen, generally from nearby tissues
or
vascular spaces and are sites where mature lymphocytes can interact effectively
with
antigen. The secondary lymphoid organs include:
a. lymph nodes, spleen, and mucosal-associated lymphoid tissues (MALT), and
bone
marrow.
b. lymph nodes, spleen, and mucosal-associated lymphoid tissues (MALT) (e.g.,
tonsils,
appendix, adenoids, Peyer's patches).
c. thymus and bone marrow.
d. lymph nodes, spleen, and thymus.
e. all of the above. - ANSWER b. lymph nodes, spleen, and mucosal-associated
lymphoid tissues (MALT) (e.g., tonsils,
appendix, adenoids, Peyer's patches).
Which of the following describes the flow of lymph through a lymph node draining
an infected tissue?
a. afferent lymphatic vessel lymph node efferent lymphatic vessel
b. efferent lymphatic vessel lymph node afferent lymphatic vessel
c. venule lymph node efferent lymphatic vessel
d. artery lymph node efferent lymphatic vessel
e. afferent lymphatic vessel lymph node artery. - ANSWER a. afferent lymphatic
vessel lymph node efferent lymphatic vessel
Which of the following pairs is mismatched?
a. T-cell activation: cell division and differentiation
b. helper T cell: kills pathogen-infected cells
c. effector B cell: plasma cell
d. plasma cell: antibody secretion
e. helper T cell: facilitates differentiation of B cells. - ANSWER b. helper T cell: kills
pathogen-infected cells
Vaccination is best described as prevention of severe disease by:
a. prior exposure to a pathogen in an attenuated or weakened form, or to an antigen
derived from that pathogen.
b. deliberate introduction of a virulent strain of an infectious agent
c. prophylactic treatment with antibiotics
d. stimulating effective innate immune responses
e. using effective public health isolation regimens such as quarantine. - ANSWER a.
prior exposure to a pathogen in an attenuated or weakened form, or to an antigen
derived from that pathogen.
Which of the following explains why immunity to influenza may appear to be
relatively short-lived?
a. Effective immunological memory fails to develop.
b. Immune responses to influenza involve innate immune mechanisms only.
c. New influenza variants able to escape prior immunity regularly.
d. The primary and secondary immune responses are equivalent.
