MCT
MCT staging correct answers lymph node aspirate, liver and spleen aspirate, bone
marrow aspirate; thoracic radiographs?
When to perform complete staging? correct answers prior to "aggressive" local therapy,
any tumor that is high grade or behaving that way (multiple or aggresively behaving
MCTs)
What is the most consistent in predicting outcome for cutaneous MCT? correct answers
Histologic grade (high grade 55-9% metestatic)
What are components of histologic grade correct answers • Location/degree of invasion
• Architecture and stromal reaction
• Nuclear morphology
• Cell morphology
• Edema and Necrosis
• Mitotic figures
surgical excision should be correct answers - 2 to 3 cm margins, 1 fascial plane deep
- With low to intermediate grade tumors, 2cm is
often adequate with 75% or more having clean
margins
When should surgery and radiation be pursued with MCT? correct answers If complete
margins not possible
• Cytoreductive surgery followed by radiation
therapy
Indications for chemo or palladia correct answers - Palliate non-resectable MCT
- As an adjuvant for MCTs that are behaving aggressively
(metastatic) or expected to do so.
Chemotherapy Options-after
local control for aggressive MCT correct answers • Vinblastine-
- expectations for cancer free period: 1.5yrs
• CCNU
• Chlorambucil
• Prednisone
• Palladia
Symptomatic treatment for MCT correct answers -H1 blockers
• diphenhydramine
MCT staging correct answers lymph node aspirate, liver and spleen aspirate, bone
marrow aspirate; thoracic radiographs?
When to perform complete staging? correct answers prior to "aggressive" local therapy,
any tumor that is high grade or behaving that way (multiple or aggresively behaving
MCTs)
What is the most consistent in predicting outcome for cutaneous MCT? correct answers
Histologic grade (high grade 55-9% metestatic)
What are components of histologic grade correct answers • Location/degree of invasion
• Architecture and stromal reaction
• Nuclear morphology
• Cell morphology
• Edema and Necrosis
• Mitotic figures
surgical excision should be correct answers - 2 to 3 cm margins, 1 fascial plane deep
- With low to intermediate grade tumors, 2cm is
often adequate with 75% or more having clean
margins
When should surgery and radiation be pursued with MCT? correct answers If complete
margins not possible
• Cytoreductive surgery followed by radiation
therapy
Indications for chemo or palladia correct answers - Palliate non-resectable MCT
- As an adjuvant for MCTs that are behaving aggressively
(metastatic) or expected to do so.
Chemotherapy Options-after
local control for aggressive MCT correct answers • Vinblastine-
- expectations for cancer free period: 1.5yrs
• CCNU
• Chlorambucil
• Prednisone
• Palladia
Symptomatic treatment for MCT correct answers -H1 blockers
• diphenhydramine
