ADVANTAGE FOR PATHOPHYSIOLOGY:
INTRODUCTORY CONCEPTS AND
CLINICAL PERSPECTIVES 2ND
EDITION THERESA CAPRIOTTI DO,
MSN, CRNP, RN QUESTIONS AND
ANSWERS WITH SOLUTIONS 2024
Macrophages - ANSWER first line of defense against foreign invaders, or antigens. they engulf, ingest,
and enzymatically break down foreign matter.
Ex. Bacteria, Pollen, viruses, and fungi
B lymphocytes and T lymphocytes - ANSWER attack specific antigens while maintaining a memory of
these antigens for future defense
Lymphomas and Leukemias - ANSWER neoplastic disorders that affect WBC's
Neoplastic- abnormal growth of cells
Lymphomas - ANSWER solid tumors of lymphoid cells, affect approximately 3% of U.S. population
Hodgkin's Lymphoma - ANSWER affects people primarily between 15-20 years of age and those aged 50-
70
One of the most curable hematologic cancers and affects 1 in 25,000 annually
Leukemias - ANSWER proliferation of cancerous WBCs
, affects approximately 350,000 annually, with 90% of those cases diagnosed in adults
3rd most common cancer in children
proliferation- rapid increase in numbers
Normal WBC count, with differential - ANSWER Normal WBC's count 5,000-10,000 cells per microliter
Neutrophils (polymorphonuclear): 40%- 80%
Immature Neutrophils (bands): 0-10%
Lymphocytes: 20%-40%
Monocytes (Macrophages) : 2%- 10%
Eosinophils: 1%-7%
Basophils: 0%-7%
pluripotent stem cells - ANSWER differentiate into each of the different types of blood cells
more names Myeloid and lymphoid stem cells
Blast cells - ANSWER immature white blood cells
Lymphocytes (developement) - ANSWER mature to a certain extent in the bone marrow, but then leave
and complete the maturation process in lymphoid tissue
B lymphocytes (developement) - ANSWER develop in plasma cells, within lymph nodes
T Lymphocytes (developement) - ANSWER maturation in thymus gland, they become T helper(cd4) and
cytotoxic T cells (CD8)