PMC Exam wk 14 Questions & Answers 2024/2025

PMC Exam wk 14 Questions & Answers 2024/2025 What form of the thyroid hormone will interact with the thyroid receptor? - ANSWERST3 How are T3 and T4 synthesized? - ANSWERS1) Iodide is ingested from water, food, and medication. 2) The sodium-iodide symporter (NIS) will transfer iodide to the thyroid gland. 3) Once iodide is in the thyroid gland, it will be oxidized to iodine. This reaction is catalyzed by Thyroid peroxidase. 4) Once intrathyroidal levels of iodine are high, this will cause the inhibition of thyroid peroxidase temporality. This stops the synthesis of T3 and T4. 5) Iodine will iodinate tyrosine residues within the thyroglobulin molecule. This produces DIT and MIT. This is referred to as iodine orangification. 6) Two molecules of DIT combine to form T4. One MIT and one DIT molecule combine to form T3. 7) T3 and T4 are released after proteolysis (cleaving) and exocytosis. What inhibits proteolysis? - ANSWERSHigh levels of intrathyroidal iodide. What is the primary pathway for the peripheral metabolism of T4? - ANSWERSDeiodination Describe the peripheral metabolism of T4 - ANSWERS5' Deiodinase converts T4 to T3.