ADVANCED PATHOPHYSIOLOGY EXAM 2 LATEST 2024 WITH UPDATED QUESTIONS AND DETAILED CORRECT ANSWERS WITH RATIONALES (ALREADY GRADED A+)

ADVANCED PATHOPHYSIOLOGY EXAM 2 LATEST 2024 WITH UPDATED QUESTIONS AND DETAILED CORRECT ANSWERS WITH RATIONALES (ALREADY GRADED A+) What plasma protein system forms a fibrinous meshwork at an inflamed site? a. Complement b. Coagulation c. Kinin d. Fibrinolysis - ANSWER-B. The coagulation (clotting) system is a group of plasma proteins that form a fibrinous meshwork at an injured or inflamed site. This protein system (1) prevents the spread of infection to adjacent tissues, (2) traps microorganisms and foreign bodies at the site of inflammation for removal by infiltrating cells (e.g., neutrophils and macrophages), (3) forms a clot that stops the bleeding, and (4) provides a framework for future repair and healing. Which component of the plasma protein system tags pathogenic microorganisms for destruction by neutrophils and macrophages? a. Complement cascade b. Coagulation system c. Kinin system d. Immune system - ANSWER-A. C3b (a component of the complement cascade) adheres to the surface of a pathogenic microorganism and serves as an efficient opsonin. Opsonins are molecules that tag microorganisms for destruction by cells of the inflammatory system, primarily neutrophils and macrophages. What is the vascular effect of histamine released from mast cells? a. Platelet adhesion b. Initiation of the clotting cascade c. Vasodilation d. Increased endothelial adhesiveness - ANSWERC. Histamine, when released from mast cells, causes vasodilation. 2 | P a g e What is an outcome of the complement cascade? a. Activation of the clotting cascade b. Prevention of the spread of infection to adjacent tissues c. Inactivation of chemical mediators such as histamine d. Lysis of bacterial cell membranes - ANSWER-D. The complement cascade can be activated by at least three different means, and its products have four functions: (1) anaphylatoxic activity, resulting in mast cell degranulation, (2) leukocyte chemotaxis, (3) opsonization, and (4) cell lysis. Which action is a purpose of the inflammatory process? a. To provide specific responses toward antigens b. To lyse cell membranes of microorganisms c. To prevent infection of the injured tissue d. To create immunity against subsequent tissue injury - ANSWER-C. If the epithelial barrier is damaged, then a highly efficient local and systemic response (inflammation) is mobilized to limit the extent of damage, to protect against infection, and to initiate the repair of damaged tissue. The response to a specific offending agent is the function of the adaptive immune response. Lysosomes lyse cell membranes. Immunity against a subsequent tissue injury occurs through the action of B cells and T cells. What causes the edema that occurs during the inflammatory process? a. Vasodilation of blood vessels b. Increased capillary permeability c. Endothelial cell expansion d. Emigration of neutrophils - ANSWER-B. The increased flow and capillary permeability result in a leakage of plasma from the vessels, causing swelling (edema) in the surrounding tissue and is solely responsible for inflammation-induced edema. Vasodilation (increased size of the blood vessels) causes slower blood velocity and increases blood flow to the injured site. Endothelial cell contraction (not expansion) leads to increased capillary permeability. Emigration of neutrophils to 3 | P a g e the area of infection/injury leads to increased destruction of the offending agent. What is the function of opsonization related to the complement cascade? a. To tag pathogenic microorganisms for destruction by neutrophils and macrophages b. To process pathogenic microorganisms so that activated lymphocytes can be created for acquired immunity c. To destroy glycoprotein cell membranes of pathogenic microorganisms d. To promote anaphylatoxic activity, resulting in mast cell degranulation - ANSWER-A. Opsonins are molecules that tag microorganisms for destruction by cells of the inflammatory system (opsonization), primarily neutrophils and macrophages.