CSO Exam 2024 Study Guide with Compete Solutions

CSO Exam 2024 Study Guide with Compete Solutions Alkylating agents - Correct Answer synthetic chemicals containing alkyl groups that attack DNA, causing strand breaks thus preventing replication and transcription of RNA Examples: Bendamustine (Treanda), Busulfan (Myleran PO/Busulflex IV, Carboplatin (paraplatin), Carmustine (BCNU), Chlorambucil (Leukeran), Ciosplatin (Platinol, CDDP), Cyclophosphamide (Cytoxan, CTX), Dacarbazine (DTIC), Ifosfamide (Ifex), Mechlorethamine (nitrogen mustard), Melphalan (Alkeran), OXaliplatin (Eloxatin), Temozolomide (temodar), Thiotepa (Thioplex) Bendamustine (treanda) - Correct Answer Treanda (alkylating agent) - IV only -B cell, NHL, CLL SE: myelosuppression, mild N/V, fatigue, fever, Hypersensitivity infusion reactions, tumor lysis syndrome Busulfan (Myleran) - Correct Answer Myleran (alkylating agent) -CML, stem cell transplant preparation, polycythemia vera Side effects: -Myelosuppresion -NVD, Mucositis -Hepatic toxicity - Adrenal insufficiency -other: pulm symptoms, insomnia, dizziness, anxiety, alopecia Additional SE: - increases uric acid! (use allopurinol, and watch for DDIs w/ thiazides, loops, niacin, low dose ASA) - Pulmonary fibrosis!! (SOB - CXR - d/c Myleran) - Seizures! (pre-medicate with anticonvulsant 12hr before and 24hr after - Hyperpigmentation of skin Carboplatin (Paraplatin) - Correct Answer Paraplatin