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Neural Circuits Lecture 5

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These revision notes delve into the developmental programs that control brain wiring to understand the cues that trigger neurons to take the correct shape and connect with appropriate partners. My revision notes also concisely explore how understanding neural circuit assembly suggests ways of treating the many neurological and psychiatric disorders that result from mistakes in brain wiring.

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Lecture 5 16th February 2017


Neural Circuits

Circuits of the spinal cord

Physiological Functions of spinal cord circuits:
 Initial processing of somatosensory (afferent) input by the CNS
 Final processing of motor (efferent) output by the CNS

Spinal nerves are highways of both somatosensory information traffic to the
spinal cord (afferent pathways) and motor information traffic from the spinal
cord to the muscles (efferent pathways)

The somatosensory system includes multiple types of sensation from the body
- light touch, pain, pressure, temperature, and joint and muscle position sense
(also called proprioception).


Sensation:
 Detection by receptors

Perception:
 Interpretation by spinal cord and brain circuits

Receptors are:
 Neurons specialised in the transduction of energy generated by external
stimuli
 Specific for a narrow range of input

Neurons in sensory systems signal events by a combination of rate, spatial and
temporal codes
 Rate code
 Frequency of APs
 Spatial code
 Summation of APs from multiple neurons
 Temporal code
 Timing of APs

Convergence and divergence
 High spatial resolution required: low convergence (e.g., cones
and bipolar cells in retina). This allows us to see in high
resolution
 Detection of weak signals required: high convergence(e.g., rods
and bipolar cells in the retina). As you need to amplify weak
signals in the environment
 Input is used for complex or multiple functions: high divergence
(e.g., vestibulo-ocular reflex).

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