PCOL 355 Final Review Questions with Answers All Correct.docx

PCOL 355 Final Review Questions with Answers All C What type of bond is broken with physical instability? A. non-covalent bonds B. covalent bonds C. ionic bonds - Answer-A. non-covalent bonds This is a true/false question. The ANDA is filed with the FDA after completion of clinical trials phases 1-3 for a generic drug product. A.True B.False - Answer-A. True Which sugar is used in special circumstances instead of sucrose in pharmaceutical syrups? A. sorbitol B. glycerin C. propylene glycol D. all of the above E. none of the above - Answer-D. all of the above Controlled release drug delivery is defined as: A. Time (temporal)-controlled only B. Spatial-controlled only C. Must be both time (temporal)-controlled and spatial-controlled - Answer-C. Must be both time (temporal)-controlled and spatial-controlled Pharmaceutical emulsions have controlled flocculation which provides which of the following? A. kinetic instability and thermodynamic instability B. kinetic stability and thermodynamic instability C. kinetic stability and thermodynamic stability D. kinetic instability and thermodynamic stability - Answer-B. kinetic stability and thermodynamic instability The Tylenol murders due to contamination led to the development of caplets. A. True B. False - Answer-A. True Pharmaceutical emulsifiers are surfactants. A.True B.False - Answer-A. True This is a true/false question. A lozenge contains a disintegrant. A. True B. False - Answer-B. False This is a true/false question. Hard gelatin capsules have more plasticizer than soft gelatin capsules. A.True B.False - Answer-B. False This is a true/false question. Higher plasticizer content lowers the glass transition temperature (Tg) of a polymer. A.True B.False - Answer-A. True Fosphenytoin is a prodrug that releases phenytoin after which biological process? A. hydrolysis B. esterase bond cleavage by esterases - Answer-A. hydrolysis What is the disintegrant in an effervescent tablet? A. carbon dioxide gas B. carbon monoxide gas C. water vapor gas - Answer-A. carbon dioxide gas This is a true or false question. Hard gelatin capsules have less plasticizer than soft gelatin capsules. A.True B.False - Answer-B. False What type of bond is broken with chemical instability? A. covalent bonds B. ionic bonds C. non-covalent bonds - Answer-A. covalent bonds A polymorph is a different amorphous form of a solid. A. True B. False - Answer-B. False Which statement is correct for passive diffusion of drug molecules? A. Driven by transporters B. Driven by energy C. Driven by drug concentration gradient - Answer-C. Driven by drug concentration gradient This is a true or false question. Emulsions have suspended solid particles. A. True B. False - Answer-B. False This is a true/false question. The ANDA is filed with the FDA after completion of clinical trials phases 1-3 for a generic drug product. A.True B.False - Answer-A. True This is a true or false question.; A prodrug molecule is pharmacologically active. A. True B. False - Answer-B. False What is the benefit of PEGylation on biological drugs, such as DNA/RNA, peptide and protein? A. Higher molecular weight B. Lower cost of manufacture C. Prolonged circulation time in the blood D. Both B and C - Answer-C. Prolonged circulation time in the blood What are the reasons to use modified cyclodextrins? A. improve solubility B. lower the cost of manufacturing C. minimize renal toxicity D. A and B E. A and C F. B and C - Answer-E. A and C What is the key issue in transdermal drug delivery? A. It is difficult for drugs to permeate through the stratum lucidum B. It is difficult for drugs to permeate through the stratum corneum C. The use of drugs used in transdermal drug delivery often result in side effects such as skin irritation and pain D. Patients often complain about the discomfort of wearing skin patches - Answer-B. It is difficult for drugs to permeate through the stratum corneum Which of the following is a typical mechanism of sustained drug release? A. erosion B. dilution C. diffusion D. Both A and C - Answer-D. Both A and C This is a true/false question. Saturated salt solutions generate relative humidity. A. True B. False - Answer-A. True Which triblock copolymer is commonly used in nanopharmaceuticals? A. PLGA B. HPMC C. PVA D. Poloxamers (Pluronics) - Answer-D. Poloxamers (Pluronics) Which of the following statements of inhaled insulin is correct? A. It is stable in room temperature B. It is a crystal form of insulin C. They are spray-dried microparticles D. Both B and C E. Both A and C - Answer-E. Both A and C This is a true/false question. Powder X-Ray Diffraction can be used to characterize the crystallinity of drug nanocrystals. A.True B.False - Answer-A. True 100% Pegylated phospholipid molecules will self-assemble to form which of the following? A. a micelle B. a bilayer C. a liposome - Answer-A. a micelle True/False. o/w emulsion is water droplets suspended in oil phase. A. True B. False - Answer-B. False Which statement is true regarding combination drug inhalation aerosol prescription products? A. They are only available as DPIs B. They are only available as MDIs C. They are available as pMDIs, DPIs, and SMIs D. They are only available as SMIs E. None of the above - Answer-C. They are available as pMDIs, DPIs, and SMIs Which of the following is a limitation of a vaginal drug delivery system? A. Variations in pH and mucus thickness B. Leakage leading to low residence time C. Higher incidence of side-effects D. All of the above E. Only answers A and B are correct - Answer-E. Only answers A and B are correct For drug particles delivered to the nasal region, which statement is correct? A. For systemic delivery at the olfactory bulb region 2-5 microns B.For local delivery at the nasal vestibules: 20-50 microns C.For systemic delivery at the nasal vestibules: 2-5 microns D.For local delivery at the turbinates: 20-50 microns - Answer-D. For local delivery at the turbinates: 20-50 microns True or False: Large carrier particles must be stripped by shear forces so that the drug can reach the lung. A.True B.False - Answer-A. True Which statement is correct regarding the different modes of particle deposition in the lungs? A.3 major modes (interception-inertia, sedimentation-gravity, diffusion-Brownian motion) and 2 minor modes (electrostatic attraction and impaction-inertia) B.3 major modes (impaction-inertia, interception-inertia, diffusion-Brownian motion) and 2 minor modes (electrostatic attraction and sedimentation-gravity) C.3 major modes (interception-inertia, sedimentation-gravity, electrostatic attraction) and 2 minor modes (impaction-inertia and diffusion-Brownian motion) D.3 major modes (impaction-inertia, sedimentation-gravity, diffusion-Brownian motion) and 2 minor modes (electrostatic attraction and interception-inertia) E.None of the above - Answer-D. 3 major modes (impaction-inertia, sedimentation- gravity, diffusion-Brownian motion) and 2 minor modes (electrostatic attraction and interception-inertia) True or False: Lung surfactant normally prevents lung collapse on inhalation, prevents lung fluid lining breakup during exhalation, and decreases the work of breathing by bringing the surface tension to near 0 mN/m. A.True B.False - Answer-A. True True or False: From lung large airway to small airway, the cross-sectional area (surface area) will decrease, while the linear velocity will increase. A.True B.False - Answer-B. False The FDA is part of the DHHS. What does DHHS stand for? - Answer-Department of Health and Human Services What is the sucrose range that most pharmaceutical syrups typically have? - Answer- 60-80% What is the maximum amount of alcohol that a pharmaceutical tincture can contain? - Answer-90% What do the following abbreviations ANDA, NDA, and INDA stand for? - Answer-ANDA: Abbreviated New Drug Application NDA: New Drug Application INDA: Investigational New Drug Application What is biological temperature (state number and units)? - Answer-37 degrees Celsius What is refrigeration temperature (state number and units)? - Answer-4 degrees Celsius List non-intravenous (i.e. not IV) types of injections - Answer-IA, IT, SQ, IM, ID What is the main component of biological bilayer membranes? A. Proteins B. Phospholipids C. Fatty acids - Answer-B. Phospholipids