NSC 4356 Exam II with complete solutions

NSC 4356 Exam IIfreebasing - correct answer smoking cocaine that has had hydrochloric salt removed from it -via dissolving cocaine HCl in ammonia and extracting via organic solvent crack - correct answer chunks of dried and hardened mixture of cocaine HCl and baking soda -crack = popping sounds when heated absorption speeds of cocaine - correct answer iv and smoking route - fasted oral admin and snorting - slower and lower cocaine levels cocaine removal - correct answer rapid elimination; "high" of only ~ 30 min or so -breakdown products of coc last much longer (benzoylegonine) cocaine + alcohol - correct answer dangerous reaction, the two drugs together have a longer duration/longer half life in the brain and are more toxic together than individually -produce cocaethylene coc blocks - correct answer DAT, NET, SERT -inhibits function and increased NT levels in synapse -stronger affinity for NET and SERT coc + DA signaling - correct answer -inhibition of reuptake via DAT binding -> can be rapid -induces increases in VTA firing coc + NAcc - correct answer increases in DA in NAcc, because cocaine binds to excitatory alpha1-adrenoreceptors (AR) -VTA DAergic neurons receive NEergic stimulation via alpha1-AR,