Final PEBC Exam Elaboration |Question and Answer| 100% Correct

Final PEBC Exam Elaboration |Question and Answer| 100% Correct Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs) *Ans* Half-life (T1/2) Inducers of Cytochrome P450 (CYP450) (4) *Ans* Barbiturates Phenytoin Carbamazepine Rifampin Inhibitors of CYP450 *Ans* Cimetidine Ketoconazole Erythromycin Isoniazid Grapefruit Their MOA utilizes intracellular receptors: *Ans* Thyroid and steroid hormones This compound's MOA utilizes transmembrane receptors: *Ans* Insulin Antidote used for organophosphate/anticholinesterase *Ans* Atropine, pralidoxime (2-PAM) Antidote used for acetaminophen (APAP) toxicity *Ans* N-acetylcysteine Antidote used for heparin toxicity *Ans* Protamine Sulfate Antidote used for warfarin toxicity *Ans* Vitamin K and Fresh frozen plasma (FFP) Antidote for tissue plasminogen activator (t-PA), streptokinase *Ans* Aminocaproic acid Antidote used for opioid toxicity *Ans* Naloxone (IV), naltrexone (PO) Antidote used for benzodiazepine toxicity *Ans* Flumazenil Interaction with this drug requires dose reduction of 6-MP(6-mercaptopurine) *Ans* Allopurinol May protect against doxorubicin cardio-toxicity by chelating iron *Ans* Dexrazoxane Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis *Ans* Bleomycin Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle inducing mitotic arrest *Ans* Paclitaxel (taxol) Anti-estrogen used for estrogen receptor + breast cancer *Ans* Tamoxifen Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonist *Ans* Odansetron Granisetron Dolasetron Palonosetron Hormone inhibiting prolactin release *Ans* Dopamine ACTH analog used for diagnosis of patients with corticosteroid abnormality *Ans* Cosyntropin Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis *Ans* Desmopressin (DDAVP) Most widely used thyroid drugs such as Synthroid and Levoxyl contain *Ans* L-thyroxine (T4) Thioamide less likely to cross placenta, inhibits peripheral conversion of T4 to T3 in high doses, and should be used with extreme caution in pregnancy *Ans* PTU PTU (propylthiouracil) MOA *Ans* Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobuli