PEBC Part I Sample Exam Questions # 2024

PEBC Part I Sample Exam Questions # 2024 Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs) *Ans*⚡Half-life (T1/2) Inducers of Cytochrome P450 (CYP450) (4) *Ans*⚡Barbiturates Phenytoin Carbamazepine Rifampin Inhibitors of CYP450 *Ans*⚡Cimetidine Ketoconazole Erythromycin Isoniazid Grapefruit Their MOA utilizes intracellular receptors: *Ans*⚡Thyroid and steroid hormones This compound's MOA utilizes transmembrane receptors: *Ans*⚡Insulin Antidote used for organophosphate/anticholinesterase *Ans*⚡Atropine, pralidoxime (2- PAM) Antidote used for acetaminophen (APAP) toxicity *Ans*⚡N-acetylcysteine Antidote used for heparin toxicity *Ans*⚡Protamine Sulfate Antidote used for warfarin toxicity *Ans*⚡Vitamin K and Fresh frozen plasma (FFP) Antidote for tissue plasminogen activator (t-PA), streptokinase *Ans*⚡Aminocaproic acid Antidote used for opioid toxicity *Ans*⚡Naloxone (IV), naltrexone (PO) Antidote used for benzodiazepine toxicity *Ans*⚡Flumazenil Interaction with this drug requires dose reduction of 6-MP(6-mercaptopurine) *Ans*⚡Allopurinol May protect against doxorubicin cardio-toxicity by chelating iron *Ans*⚡Dexrazoxane Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis *Ans*⚡Bleomycin Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle inducing mitotic arrest *Ans*⚡Paclitaxel (taxol) Anti-estrogen used for estrogen receptor + breast cancer *Ans*⚡Tamoxifen Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonist *Ans*⚡Odansetron Granisetron Dolasetron Palonosetron Hormone inhibiting prolactin release *Ans*⚡Dopamine ACTH analog used for diagnosis of patients with corticosteroid abnormality *Ans*⚡Cosyntropin Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis *Ans*⚡Desmopressin (DDAVP) Most widely used thyroid drugs such as Synthroid and Levoxyl contain *Ans*⚡Lthyroxine (T4) Thioamide less likely to cross placenta, inhibits peripheral conversion of T4 to T3 in high doses, and should be used with extreme caution in pregnancy *Ans*⚡PTU PTU (propylthiouracil) MOA *Ans*⚡Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin Some side effects of corticosteroids *Ans*⚡Hyperglycemia Osteopenia Impaired wound healing inc. risk of infection inc. appetitie HTN Edema PUD Euphoria Psychosis Diuretic used to antagonize aldosterone receptors *Ans*⚡Spironolactone Common SE of spironolactone *Ans*⚡Gynecomastia and hyperkalemia Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and currently being tested for treatment of breast cancer (Stars study) *Ans*⚡Raloxifene Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy *Ans*⚡Diethylstillbestrol (DES) Converted to more active form DHT by 5 alpha-reductase *Ans*⚡Testosterone Product of proinsulin cleavage used to assess insulin production *Ans*⚡C-peptide Long acting insulin *Ans*⚡Ultralente (humulin U) Amino acid derivative for treatment of Type II diabetes *Ans*⚡Nateglinide Increase bone density, also being tested for breast CA tx. *Ans*⚡Raloxifene (SERMselective estrogen receptor modulator) Used intranasally and decreases bone resorption *Ans*⚡Calcitonin (salmon prep) Drug that causes contraction of the uterus *Ans*⚡Oxytocin Distribution of histamine receptors H1, H2, and H3 *Ans*⚡Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively Prototype antagonist of H1 and H2 receptors *Ans*⚡Diphenhydramine 1st generation antihistamine that is highly sedating *Ans*⚡Diphenhydramine 2nd generation antihistamines *Ans*⚡Fexofenadine Loratadine Cetirizine H2 blocker that causes the most interactions with other drugs *Ans*⚡Cimetidine 5HT-1D/1B agonist used for migraine headaches *Ans*⚡Sumatriptan Naratriptan Rizatriptan Agents for reduction of postpartum bleeding *Ans*⚡Oxytocin and ergonovine Agents used in treatment of carcinoid tumor *An