Acetaminophen || A Verified A+ Pass.

what is Acetaminophen's availability? correct answers suppository; tablet/caplet; extended release tablet/capsule; liquid, injection what is Acetaminophen's action of mechanism correct answers produces analgesia by elevation of pain threshold, inhibits action of endogenous pyrogens on the heat-regulating centers in the brain by blocking formation and release of prostaglandins in the CNS how does Acetaminophen inhibit endogenous pyrogens? correct answers inhibits their action on heat-regulating centers in brain by blocking formation & release of prostaglandins in CNS pyrogens correct answers a substance, typically produced by a bacterium, that produces fever when introduced or released into the blood. prostaglandins correct answers Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. how are prostaglandins formulated? correct answers generated from arachidonate by the action of cyclooxygenase (COX) isoenzymes how are prostaglandins inhibited? correct answers biosynthesis is blocked by nonsteroidal anti-inflammatory drugs (NSAIDs), including those selective for inhibition of COX-2. what is the therapeutic effect of acetaminophen? correct answers provides temporary analgesia for mild to moderate pain, lowers body temp in individuals with a fever what are the uses of acetaminophen correct answers fever reduction, temporary relief of mild to moderate pain. substitute for aspirin what contraindicates acetaminophen? correct answers sensitivity to acetaminophen or phenacetin, liver failure what is associated with acetaminophin doses in excess of 4000mg/day? correct answers acute liver failure what are acetaminophen's cautious uses? correct answers repeated administration, especially in patients with anemia, G6PD deficiency, renal or hepatic disease, arthritic or rheumatoid condition in children 12 and younger, alcoholism, malnutrition, thrombocytopenia, bone marrow depression, immunosuppresion, pregnancy, what is the adult dose of acetaminophen? correct answers 325-650 mg q4-6h PO 650 mg q 4-6h PR 1000 mg q6h or 650 q4h prn IV