ACAAI Board Review Diagnostic Modalities Exam with Questions and Answers

ACAAI Board Review Diagnostic Modalities Exam with Questions and Answers Where are the highest concentrations of IgE- producing plasma cells? ANSWER Tonsils and adenoids Polymorphisms of CCL11 (eotaxin) are associated with serum total IgE; ANSWER increased in blacks, decreased in whites. Measurement of Total IgE Nephelometry or immunoassay ANSWER 1 IU/mL = 2.44 ng/mL Standardized vs. World Health Organization reference IgE serum Total IgE range. ANSWER Generally nondiagnostic of allergic disease due to wide ranges (Atopic diseases: Atopic dermatitis: mean 978 IU/L; range 1.3-65,208) and wide overlap in the IgE distribution of atopic and nonatopic populations Which part of the back (upper or lower) has greater skin reactivity for skin testing? ANSWER Upper back False-positive SPT results to tree pollen can be seen in patients allergic to ANSWER honeybee stings due to cross-reactive carbohydrate determinants in honeybee venom. component peanut diagnostics ANSWER Best studied for peanut: Ara h 8 peanut— Bet V 1 family (birch)—labile—oropharyngeal symptoms Ara h 9 peanut and Pru p 3 peach—lipid transfer protein—stable—