TEST BANK FOR TIETZ FUNDAMENTALS OF CLINICAL CHEMISTRY, 6TH EDITION, BURTIS
Burtis, et al: Tietz Fundamentals of Clinical Chemistry, 6th Edition Test Bank Chapter 1: Principles of Clinical Chemistry and Evidence Based Laboratory Medicine MULTIPLE CHOICE 1. During diagnostic accuracy studies in evidence-based laboratory medicine, a laboratory test being studied, for example, produces results that are compared with the “gold standard” of testing, which would be the currently used assay or assay system. The test of interest is referred to as A. index test. B. reference standard. C. outcome study. D. practice test. ANS: A An index test is the method being assessed, and the results of the index test are compared with the reference standard, which is the current best practice, or method, used to obtain results. DIF: 1 REF: Pages 1, 4 OBJ: 5 2. In reading a research article, you determine that the study design was flawed because there was no control group. This is an example of a weakness in A. internal reliability. B. internal validity. C. external reliability. D. external validity. ANS: B Problems in the design of a study are considered to be poor internal validity and will produce systematic error because the estimates of diagnostic accuracy differ from those one would have obtained using an optimal design for the study. DIF: 2 REF: Pages 1, 4 OBJ: 6 3. When developing clinical practice guidelines, what is the critical first step? A. Requesting input from health insurance companies and government officials B. Preparing a cost analysis based on patient needs C. Determining the intended group that will be directly involved with implementation D. Selecting and refining the topic upon which the investigation will center ANS: D
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