GMS6510 Review Exam 2 Questions and Answers Rated A+

GMS6510 Review Exam 2 Questions and Answers Rated A+ After absorption, which form of nicotine predominates in the body in terms of charge? Neutral What type of receptor is the nAChR? Ligand gated ion channel Which nAChR subunit binds to nicotine? alpha(a) To which nAChR state does nicotine bind with the greatest affinity? Desensitized Through which route of administration are maximal plasma nicotine concentrations obtained the fastest? Cigarette Through which route of administration are maximal plasma nicotine concentrations maintained for the shortest time? Cigarette True or false? Smoking the same number of low-nicotine cigarettes as standard cigarettes results in lower nicotine concentrations in the blood. True Nicotine is primarily metabolized by which enzyme? CYP2A6 According to the Fagerström test, smoking at what part of the day is most associated with dependence? Morning Release of which hormone is responsible for the "reward" achieved through nicotine consumption? Dopamine In the battle between "nature" and "nurture," which plays a bigger role in leading to nicotine dependence? Nuture Which form of NRT attains the highest plasma levels of nicotine? 4mg gum Which form of NRT maintains the most constant plasma levels of nicotine over long periods using only one administration? Patch Which type of therapy has the highest success rates in terms of smoking cessation? Varenicline Which type of cessation therapy is associated with a high risk of seizures? Bupropion Roughly what fraction of lung cancer cases could be prevented with the absence of smoking? 7/8 What functional group is formed on BaP that ultimately causes adduct formation? Epoxide What enzyme is responsible for activating PAHs? CYP1A1 In tobacco-associated COPD, is the ability of the b