GMS 6510 Cannabis Review Latest Update Graded A+

GMS 6510 Cannabis Review Latest Update Graded A+ Three different types of cannabis plants Cannabis sativa, Cannabis indica, and Cannabis ruderalis History of Cannabis Use of cannabis fibers dates back to roughly 8,000 BC, first medical use was in China 5,000 years ago, appears in Hindu holy books, and introduced into Western medicine in the 1800s 1961 Single Convention on Narcotic Drugs Prohibited production and supply other than for medical purposes 1971 Convention on Psychotropic Substances Generated the current schedule drugs, placed THC in Schedule I, and other cannabinoids were not regulated Chemical makeup of Cannabis Over 100 cannabinoids, THC responsible for nearly all psychoactive effects, other compounds can modulate THC effects, and cannabinoid content varies between strains, 1960s marijuana was 2-5% THC, today is 12% THC THC levels in plant Absent in roots and seeds Present at low levels in stems Present in leaves 2-3% High in flowers up to 25% Cannabinoids 11 types of cannabinoids Δ9-THC and CBD are two Historically, all NIH supplied marijuana has been low THC, high CBD Δ9-THC (tetrahydrocannabinol) Only psychoactive cannabinoid Δ9-THC-acid is not psychoactive converted to Δ9-THC during heating or combustion CBD (cannabidiol) Produces many of the same effects as THC, but not psychoactive Reduces psychoactive properties of THC Concentration in street marijuana has dropped to near 0 CBD-acid is converted to CBD during combustion CBD-acid is 100-1000x more potent than CBD as an antiemetic Administration of Cannabis Smoking Vaporizing, reduces toxin formation Eating Oral tinctures Topical Smoking Most common Bioavailability around 25%, but highly variable, THC plasma Cmax in 6-10 minutes, 60% after 15 minutes, and 20% after 30 minutes Oral Oral (Edibles or THC pill) Bioavailability around 6% Higher when in oils THC plasma Cmax in 2-6 hours Distribution THC is highly lipophilic Quickly sequestered by organs with high blood flow THC