Advanced Pharmacology Final Exam Review Questions with Verified Solutions

Advanced Pharmacology Final Exam Review Questions with Verified Solutions Why are nitrate-free periods every 24 hours necessary for the patient on nitroglycerin therapy? To inhibit the development of tolerance What does a low level of thyroid-stimulating hormone indicate? Hyperthroidism What would be the best option to treat a newly diagnosed patient with a low TSH level with? Propanolol (Inderal) Spironoaldactone (Aldactone) has what mechanism of action (MOA)? Aldosterone antagonist Heparin exerts its therapeutic action by what? Upregulating the activity of one of the body's natural anticoagulant molecules, antithrombin III What physiologic action happens when the offending drug is administered during an anaphylactic reaction. Mast cells liberate large doses of histamine. What are two systemic psoriasis medications? Photo-therapy and topical corticosteroids What is the first choice of drug therapy for the majority of patients with uncomplicated stage I hypertension? Thiazide diuretics What is the effect of cardiac glycosides? Digitalis glycosides have a negative chronotropic effect on the cardiac muscle cells. Amenorrhea is the most common side effect of which birth control medication? Medroxyprogesterone (Depo-Provera) What is an anti-hypertensive agent which competes with epinephrine for available beta-receptor sites? Atenolol (Tenormin) What type of action does nitrates have on the body? Reduction in systemic venous tone. What is the recommended level of low-density lipoprotein cholesterol (LDL) for patients with known coronary artery disease? 100mg/dl or less. What is the MOA of group IV anti-dysrhythmia drugs? Depressing phase 4 depolarization and lengthening phases 1 and 2 repolarization. Which drug therapy should be used to lower the serum concentration of thyroid hormones and re-establish eumetabolic state in a patient with Graves' disease? Anti-thyroid drugs. Which type of diuretic would be used for a stage I hypertension in a patient with renal insufficiency? Loop diuretic. What drug should be considered as first-line therapy for a client with hypertension and heart failure? Enalapril (Vasotec) Which drug is considered safe for hypertension treatment during pregnancy? Methyldopa (Aldomet) What drug will reduce afterload because it