UNE Medical Biochemistry Exam 1 Questions With 100% Correct Answers

UNE Medical Biochemistry Exam 1 Questions With 100% Correct Answers what percentage of water is in the body? - answer60% Relationship between protons and acids & bases - answerAcids donate proton. Bases accept proton Strong Acids Vs Weak Acids - answerStrong acids fully dissociate (100%) and weak acids partially dissociate properties of water - answerdipole dipole polar H bonding dissolves electrolytes ( CL /Na) Small Kd- doesn't dissociate alot kw ion product - answer10^-14 pH - answer-log[H+] biological PH - answer7.4 types of buffers - answerphosphates, bicarbonate, proteins Buffers - answerweak acid and conjugate base Ka - answerhow well acid can dissociate pka - answer-log(Ka) 50%dissociation Buffers work best when? - answerph=pka within +/- 1 ph unit of pka Henderson-Hasselbalch equation - answerpH= pka + log A-/HA pH<pKa - answerprotonated pH>pKa - answerionized amino acids are linked together by - answerpeptide bonds between carboxyl and amino group what's special about histidine pka? - answerclose to biological PH of 7.4 so it can act as an donor or acceptor nonpolar amino acids - answerglycine alanine proline valine leucine isoleucine Aromatic Amino Acids - answerphenylalanine, tyrosine, tryptophan polar uncharged amino acids - answerasparagine glutamine serine threonine sulfur containing amino acids - answermethionine cysteine charged amino acids - answeraspartate glutamate arginine lysine histidine which 3 amino acids carry ammonia? - answerglutamine, glutamate, alanine which 3 amino acids can be phosphorylated? - answerserine, threonine, tyrosine pka of COOH and NH2 - answer2 and 9 what interactions can proteins have? - answerelectrostatic forces dipole dipole h bonding hydrophobic interactions Alpha helix bonding - answerh bond between carbonyl O and amide 4 residues down R groups stick out of helix hydrophobic core beta sheet bonding - answerh bonding between carbonyl O and amide across from each other R groups stick out Amyloid plaques - answeraggregates of Amino acids Motif Vs Fold - answersecondary (common arrangement) VS TERTIARY types of folds - answeractin and nucleotide binding fold prosthetic group - answermolecule that forms a permanent part of a protein ex: heme group in Hg Apo/Holo protein - answerwithout or with prosthetic/heme group Mg binding - answernon cooperative hyperbolic binding curve Hg binding - answerpositive cooperativity - needs quarternry structure sigmoidal binding curve T state vs R state - answerlow oxygen affinity Vs high affinity when oxygen binds to Hg what kind of bonds does it break? - answersalt bridges. Bohr effect - answerlowered pH decreases the O2 binding affinity for hemoglobin, releasing more O2 into the body Glycosylated hemoglobin - answerused to test glucose- HGA1C 4 types of catalysis enzymes use - answertransition state stabilization acid base catalysis