Antifungal Agents-Questions and Answers Graded A+

Antifungal Agents-Questions and Answers Graded A+ Treating Systemic Mycoses - ANSWER-Treatment can be difficult. Infections often resist treatment. Treatment may require prolonged therapy with drugs that frequently prove toxic. opportunisitc systematic infections - ANSWER-Candidiasis, aspergillosis, cryptococcosis, mucormycosis nonopportunistic systematic infections - ANSWER-Sporotrichosis, blastomycosis, histoplasmosis, Superficial mycoses infections - ANSWER-Candidiasis Dermatophytes Four Classes of Antifungal Drugs - ANSWER-1. Polyene antibiotics 2. Azoles 3. Echinocandins 4. Pyrimidine analogs Polyene antibiotics MOA and example - ANSWER-Amphotericin B Bind to ergosterol, disrupting the fungal cell membrane Azoles MOA and example - ANSWER-FLuco, Itra, Keto conazole Inhibits synthesis of ergosterol, disrupting fungal cell membrane Echinocandins MOA - ANSWER-disrupts synthesis of fungal cell wall through 1-3-D glucan Pyrimidine analogs MOA - ANSWER-Disrupt DNA and RNA synthesis Amphotericin B overview - ANSWER-Broad-spectrum antifungal agent (also used against some protozoa) Amphotericin B toxicity - ANSWER-Infusion reaction and renal damage occur in all patients to varying degrees Must be given IV - no oral administration Amphotericin B uses - ANSWER-Drug of choice for most systemic mycoses