ONS/ONCC CHEMOTHERAPY/IMMUNOTHERAPY LESSON 11: TARGETED THERAPIES Exam | Questions & 100% Correct Answers (Verified) | Latest Update | Grade A+

How targeted therapy and chemo differ Correct Answer: -targeted therapies act on specific molecular targets on or within the cells that are associated with cancer, whereas standard chemo act on all rapidly dividing cells-chemo has more SEs-targeted therapy ae chosen and designed to interact with their target on or within the cells, whereas chemo were IDed becaused they kill cells-targeted therapies are often cytostatic (they block tumor cell proliferation) whereas chemo agents are cytotoxic (kill tumor cells) Goals of targeted therapy Correct Answer: -disease cure when used as primary or adjuvant therapy -improving overall response or increase disease-free survival when used in combination with conventional therapies -controlling or stabilizing disease -maintaining or enhancing quality of life 2 -decreasing the severity of toxicities from other therapies Ligand Correct Answer: a substance that forms a complex with another biomolecule to exert a biologic effect Ligand Binding Correct Answer: process by which the ligand attaches to a specific receptor site and activates that receptor, activating the signaling pathway Dimerization Correct Answer: two monomers that are side-by-side on the surface of the cell are paired and activated by a ligand, which causes a series of signals Kinase Correct Answer: type of enzyme that adds chemicals called phosphates to other molecules such as sugars or proteins causing other molecules in the cell to become either active or inactive phosphorylation Correct Answer: activation of a chemical process to initiate signaling targeted therapies work by doing the following 3 Correct Answer: 1. blocking angiogenesis 2. blocking signals inside or outside the cell 3. delivering toxic substances to the cell 4. stimulating the body's immune system BCR/ABL Correct Answer: -fusion protein tyrosine kinase formed with a gene translocation occurs between gene 9 and 22-gene abnormality called the Philadelphia chromosome seen in CML and ALL VEGF Correct Answer: this is the primary angiogenic factor produced by cells mTOR Correct Answer: -target of rapamycin-a protein that tells cells when to grow, divide, and survive Two ways that angiogenesis inhibitors work Correct Answer: 1. some intergere with action of VEGF which stimulates n ew blood vessel formation2. others target their molecules that stimulate new blood vessel growth Small Molecule Compound Targeted Therapie