NSG 533 Adv Pharm: Module 1: GI: Chp 17 100% Solved

NSG 533 Adv Pharm: Module 1: GI: Chp 17 Which drug class is most effective in treating erosive lesions:? - PPIs Name 4 H2RAs: - Cimetidine (Tagamet) Famotidine (Pepcid) Ranitidine (Zantac) Nizatidine (Axid) What is the action of H2RAs? - Decrease acid secretion by blocking histamine 2-receptors in gastric parietal cells Name 4 benefits of H2RAs - 1. Relieve GERD symptoms 2. Can be administered prophylactically 3. More effective at controlling chronic GERD symptoms than ANTACIDS 4. Intermittent & routine dosing possible based on degree of symptom control needed. Name 2 drawbacks of H2RAs - 1. Less effective in controlling chronic GERD symptoms than PPIs 2. Renal elimination may require dose adjustment in kidney dysfunction patients What are the side effects associated with H2RAs? - H/A, nausea (Cimetidine), weak inhibitor, common drug interactions, gynecomastia, & Vit B-12 deficiency which affects patients' tolerance Name the benefits of Antacids - 1. Useful for intermittent treatment of GERD symptoms 2. Immediate symptom relief 3. Usually well-tolerated