PC707 PHARMACOLOGY FINAL- SAFETY EXAM QUESTIONS WITH CORRECT ANSWERS

PC707 PHARMACOLOGY FINAL- SAFETY EXAM QUESTIONS WITH CORRECT ANSWERS Does the pdr provide up to date info on pregnancy and lactation? - answer ️️ -no, It is a compilation of package inserts, without much updating Best resources for drugs in pregnancy and lactation - answer ️️ -lactmed and otis (organization of tetraology information specialists) Do medical foods need to be administered under the direction of a provider? - answer ️️ -yes What are risk factors for drug resistant pathogens - answer ️️ -recent antibiotic use, younger than 2, older than 65, daycare attendance (not college), exposure to young children, comorbidities, recent hospitalizations, immunosuppression. What are the safest remedies/drugs to use for constipation in pregnancy? - answer ️️ -bulk forming laxatives and glycerin suppositories Metformin is contraindicated in those with kidney disease, at what creatinine levels should metformin not be given - answer ️️ -serum creatinine greater than 1.5 in men and 1.4 in women Drug half life - answer ️️ -the time it takes for the drug concentration to decrease by half in the serum Metabolism - answer ️️ -the chemical alteration of drugs by the body's enzymes Type 1 reaction - answer ️️ -ige- mediated. Immediate hypersensitivty reaction, atopic reaction, hives, anaphlaxysis, angioedema Type 2 reaction - answer ️️ -antibody dependent cytotoxicity (i.e. heparin induced thrombocytopenia) Type 3 reaction - answer ️️ -immune complex hypersensitivity (arthus reaction to tetanus vaccine) Type 4 reaction - answer ️️ -cell mediated delayed hypersenstivity: drug rash, eosinophilia and systemic syndrome. Can schedule ii drugs have refills? - answer ️️ -no, New rx needs to be written for each 30 day supply Carbamazepine and lamictal have similar black box warnings for what? - answer ️️ -stevens johnson syndrome What class of cardiac meds are first line for pregnancy? - answer ️️ -ccb calcium channel blockers The use of opthalmic beta blockers in addition to systemic beta blockers may cause what? - answer ️️ -additive beta blockage effects The use of opthalmic timolol while the patient is already taking a beta blocker may cause what symptoms? - answer ️️ -bradycardia or asystole Symptoms of rhabdomyolysis include what? - answer ️️ -abdominal pain, dark urine, severe muscle pain. Rhabdomyolysis - answer ️️ -a syndrome caused by injury to skeletal muscle- involves leakage of large quantities of potentially toxic intracellular contents into plasma. What drug class can cause rhabdomylosis - answer ️️ -statins: Although mild muscle pain is a relatively common side effect of statins, some people who take statin may have severe muscle pain. The higher the dose of statins, the higher the risk of rhabdomyolysis becomes. If one nsaid is not effective for a patient, could another nsaid be effective for the same patient - answer ️️ -yes Primary principle in stepwise approach to asthma - answer ️️ -use the level of conrol to decide wether to maintain or adjust therapy What step wise approach would you take to manage mild to moderate contact dermatitis? - answer ️️ -1. Remove any causative agents/ triggers 2. Try a topical corticosteroid 3. Move to oral steroids last What is the best overall long term treatment for chronic generalized anxiety? - answer ️️ -ssri or snri (benzos have too high dependency level, only use for acute and short term) Statin strength (high intensity, moderate, and low) - answer ️️ -look at the strength of the drug and what it does, not just the milligr