PC707 Final Exam questions with 100 % correct answers | verified

grapefruit juice can _____levels of other drugs that use the CYP450 pathway - Answer-increase grapefruit juice is an - Answer-inhibitor Amount of refills for schedule II drug - Answer-no refills-- must be rewritten every time broad-spectrum abx increase risk for - Answer-superinfection ____ gen cephalosporins have highest cross reactivity with type I pcn allergy - Answer-1st What reaction can occur with cephalosporins and ETOH? - Answer-disulfiram reaction cephalosporins may increase - Answer-bleeding d/t interference with vitamin K absorption D2D with clarithromycin --> kidney damage - Answer-calcium channel blockers macrolides should be avoided with what class of drugs? - Answer-statins (can increase statin levels to toxicity) gentamycin and tobramycin are - Answer-aminoglycosides BBW for aminoglycosides - Answer-Nephrotoxicity Ototoxicity Neurotoxicity NON aminoglycosides CI (2) - Answer-pregnancy renal impairmentBBW for clindamycin - Answer-C. Diff BBW vancomycin - Answer-increased risk of mortality with renal impairment Drug that can cause red man syndrome if infused too rapidly - Answer-vancomycin what levels should be monitored with vanc - Answer-serum vanc levels ciprofloxacin is a - Answer-fluoroquinolones BBW for fluoroquinolones - Answer-tendon rupture fluoroquinolones CI in (4) - Answer-pregnancy lactation children under 18 ASVD why should fluoroquinolones be avoided in pts with ASVD, marfans, and HTN? - Answer-increased risk for aortic aneurysm common SE of fluorquinolone - Answer-photosensitivity Avoid macrobid in - Answer-3rd trimester, breastfeeding infant less than 1 month old macrobid in a pt with G6DP deficiency - Answer-can cause hemolytic anemia Why should sulfonamides (bactrim) be avoided in 1st and 3rd trimesters? - Answer-increased risk of cleft palate CVD defects, and kernicterus