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AAB MT Hematology | 232 Questions with 100% Correct Answers | Verified | Latest Update 2024

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AAB MT Hematology | 232 Questions with 100% Correct Answers | Verified | Latest Update 2024 What is hemoglobin composed of? - 4 heme, 4 iron, 4 globins What disorder does a defect in heme synthesis lead to? - Porphyria Porphyria - Deficiency in the enzymes of the porphyrin pathway leads to insufficient production of heme. The principal problem in these deficiencies is the accumulation of porphyrins, the heme precursors, which are toxic to tissue in high concentrations. What is methemoglobin? - Methemoglobin is a form of hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to bind oxygen. However, the ferric iron has an increased affinity for bound oxygen. When methemoglobin concentration is elevated in red blood cells, tissue hypoxia can occur. What is the function of the enzyme methemoglobin-cytochrome C reductase in a red blood cell? - To keep iron in the ferrous state What product is formed when ferrous iron of hemoglobin is oxidized to the ferric state? - Methemoglobin

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