Toxicology summary
Writt en by dr. A. Lemdjad on 2 february 2023, Nijmegen.
, Inhoud
Lecture 1: Biotransformation.................................................................................................................3
Phase I reactions.................................................................................................................................3
Phase II reactions................................................................................................................................4
Lecture 2: Toxicokinetics........................................................................................................................5
Half-life...............................................................................................................................................6
Volume of distribution........................................................................................................................6
Clearance............................................................................................................................................6
Area under the concentration-time curve..........................................................................................6
Steady-state concentration................................................................................................................6
Lecture 3 – Digitalis-like compounds in animals and plants...................................................................7
Lecture 4 – Chemical carcinogenesis......................................................................................................8
General carcinogenesis.......................................................................................................................8
Biotransformation..............................................................................................................................8
Postlabeling analysis of DNA adducts.................................................................................................9
Mutated proteins in cancer................................................................................................................9
Immunotoxins.....................................................................................................................................9
Lecture 5 – Human health risk assessment............................................................................................9
Lecture 6 – Mechanisms in toxicity......................................................................................................11
Stage I: delivery................................................................................................................................11
Stage II: interaction with target molecule........................................................................................11
Benzo[a]pyrene............................................................................................................................11
Dioxin (TCCD)................................................................................................................................11
TCDD.............................................................................................................................................12
Diethylstilbestrol..........................................................................................................................12
Haptenization...............................................................................................................................12
Stage III: cellular dysfunction and injury...........................................................................................13
Writt en by dr. A. Lemdjad on 2 february 2023, Nijmegen.
, Inhoud
Lecture 1: Biotransformation.................................................................................................................3
Phase I reactions.................................................................................................................................3
Phase II reactions................................................................................................................................4
Lecture 2: Toxicokinetics........................................................................................................................5
Half-life...............................................................................................................................................6
Volume of distribution........................................................................................................................6
Clearance............................................................................................................................................6
Area under the concentration-time curve..........................................................................................6
Steady-state concentration................................................................................................................6
Lecture 3 – Digitalis-like compounds in animals and plants...................................................................7
Lecture 4 – Chemical carcinogenesis......................................................................................................8
General carcinogenesis.......................................................................................................................8
Biotransformation..............................................................................................................................8
Postlabeling analysis of DNA adducts.................................................................................................9
Mutated proteins in cancer................................................................................................................9
Immunotoxins.....................................................................................................................................9
Lecture 5 – Human health risk assessment............................................................................................9
Lecture 6 – Mechanisms in toxicity......................................................................................................11
Stage I: delivery................................................................................................................................11
Stage II: interaction with target molecule........................................................................................11
Benzo[a]pyrene............................................................................................................................11
Dioxin (TCCD)................................................................................................................................11
TCDD.............................................................................................................................................12
Diethylstilbestrol..........................................................................................................................12
Haptenization...............................................................................................................................12
Stage III: cellular dysfunction and injury...........................................................................................13
