MED CHEM EXAM 2024 WITH MS

SECTION A MULTIPLE CHOICE QUESTIONS ATTEMPT ALL THE QUESTIONS FROM THIS SECTION BY SELECTING THE MOST SUITABLE ALTERNATIVE FROM THE CHOICES GIVEN 1. The aim of structural modification of a drug is NOT to: A. Improve its biological activity B. Improve its physical appearance C. Introduce a different type of activity D. Introduce activity where there was none. 2. The lipid solubility of a drug affects the following factors except: A. Partitioning into the CNS B. Stereochemistry C. Rate of elimination from the body D. Degree of ionization 3. Ferguson’s principle states that: A. The concentration of drug in the plasma is inversely proportional to its biological activity B. The concentration of drug in the plasma is directly proportional to its biological activity C. The activity of a drug is based on its structure rather than its physicochemical properties D. Drugs can only be classified based on their chemical structure 4. From the statements below, select that which does not highlight the differences between structurally specific and structurally non specific drugs:. STRUCTURALLY SPECIFIC STRUCTURALLY NON-SPECIFIC A. Slight structural modification causes no change in activity Slight change in structure will greatly affect the activity B. Drugs with similar activity are structurally related Drugs with unrelated chemical structure may produce the same activity C. They interact with specific sites on the receptors or by a specific mechanism They do not interact with receptors D. Biological activity depends on the structure Biological activity is not dependent on the structure but rather on the physicochemical properties 5. Oxidative metabolic routes include the following except: A. Aromatic hydroxylation B. Acetylation