CCTC NUR 106 UNIT 7
CARDIOVASCULAR/ URINARY SYSTEM
DRUGS
Atorvastatin Pharm. Class: - correct answer HMG-CoA reductase inhibitor, Statin
Atorvastatin Therapeutic Class: - correct answer Antihyperlipidemic
Atorvastatin Action: - correct answer Increases HDL, decreases LDL and total cholesterol by inhibiting
HMG-CoA reductase. Liver makes less cholesterol & responds by making more LDL receptors to remove
cholesterol from blood
Atorvastatin Indications: - correct answer Hypercholesterolemia
Adverse effects of atorvastatin: - correct answer Headache, Intestinal cramping, Diarrhea, Constipation,
liver toxicity
Serious adverse effects of atorvastatin: - correct answer Myopathy can progress to Rhabdomyolysis
What is myopathy? - correct answer Pain in muscles and joints
what is rhabdomyolysis? - correct answer breakdown of muscle protein causing kidney damage
Contraindications for atorvastatin: - correct answer serious liver disease, pregnancy and lactation
(category X), Multiple sclerosis, rhabdomyolysis
Interactions with atorvastatin: - correct answer Grapefruit Juice, oral contraceptives, digoxin,
erythromycin, HIV protease inhibitors, Azole antifungals, telaprevir, cyclosporine and niacin
,Nursing implications for atorvastatin: - correct answer Monitor for myopathy, measure CPK if muscle
pain occurs, monitor liver function test
Atorvastatin Admin: - correct answer In the evening with a meal because you make more cholesterol in
the evening
Primary goal in atorvastatin: - correct answer reduce the risk of MI and stroke
Grapefruit Juice inhibits metabolism in: - correct answer Statins
Route for atorvastatin: - correct answer PO
Onset, Peak, Duration for atorvastatin: - correct answer Onset: 2 weeks Peak: 1-2 hours Duration:
unknown
Cholestyramine Pharm. Class: - correct answer Bile Acid Sequestrant
Cholestyramine Therapeutic Class: - correct answer Antihyperlipidemic
Cholestyramine Pharmacokinetics: - correct answer Absorption - no
Distribution - no
Metabolized - no
Excretion - stool
Cholestyramine Action: - correct answer binds to bile acids & increases LDL receptors on hepatocytes
(causes a decrease in LDL)
Cholestyramine Indications: - correct answer Hypercholesterolemia
, Cholestyramine Admin: - correct answer Mix with 60-180 mL of WATER, NONCARBONATED beverages,
highly liquid soups, or pulpy fruits (applesauce, crushed pineapple). Drink immediately. DONT TAKE
WITH OTHER MEDS.
Serious Adverse Effects for Cholestyramine: - correct answer GI obstruction, metabolic acidosis, mal-
absorption syndrome; bleeding tendency
Contraindications for cholestyramine: - correct answer GI disorders, triglyeride levels > 400 mg/dl,
Pregnancy Category B
Drug interactions with cholestyramine: - correct answer Increase effects: Warfarin, anticoagulants by
decreasing levels of vitamin K.
Decrease effects: Digoxin, penicillin, Fe supplement, thyroid hormone, & thiazide diuretics
Nursing Interventions for Cholestyramine: - correct answer evaluate therapeutic outcomes 1 month of
therapy, dissolve completely before admin., dont take with other meds
Niacin Action: - correct answer decreases production of VLDL, which lowers serum triglyceride and LDL,
and increases HDL
Niacin adverse effects: - correct answer flushing, rash, diarrhea, hepatotoxicity, hyperglycemia,
hyperuricemia
Niacin Admin instructions: - correct answer take aspirin 30 minutes prior to reduce flush
Niacin Therapeutic Class: - correct answer B-Complex vitamin (B3)
Niacin Uses: - correct answer Clients at risk for pancreatitis and elevated triglyceride levels
Niacin Contraindications: - correct answer Pregnancy, liver disease, gout, DM, asymptomatic
hyperuricemia, peptic ulcer disease
CARDIOVASCULAR/ URINARY SYSTEM
DRUGS
Atorvastatin Pharm. Class: - correct answer HMG-CoA reductase inhibitor, Statin
Atorvastatin Therapeutic Class: - correct answer Antihyperlipidemic
Atorvastatin Action: - correct answer Increases HDL, decreases LDL and total cholesterol by inhibiting
HMG-CoA reductase. Liver makes less cholesterol & responds by making more LDL receptors to remove
cholesterol from blood
Atorvastatin Indications: - correct answer Hypercholesterolemia
Adverse effects of atorvastatin: - correct answer Headache, Intestinal cramping, Diarrhea, Constipation,
liver toxicity
Serious adverse effects of atorvastatin: - correct answer Myopathy can progress to Rhabdomyolysis
What is myopathy? - correct answer Pain in muscles and joints
what is rhabdomyolysis? - correct answer breakdown of muscle protein causing kidney damage
Contraindications for atorvastatin: - correct answer serious liver disease, pregnancy and lactation
(category X), Multiple sclerosis, rhabdomyolysis
Interactions with atorvastatin: - correct answer Grapefruit Juice, oral contraceptives, digoxin,
erythromycin, HIV protease inhibitors, Azole antifungals, telaprevir, cyclosporine and niacin
,Nursing implications for atorvastatin: - correct answer Monitor for myopathy, measure CPK if muscle
pain occurs, monitor liver function test
Atorvastatin Admin: - correct answer In the evening with a meal because you make more cholesterol in
the evening
Primary goal in atorvastatin: - correct answer reduce the risk of MI and stroke
Grapefruit Juice inhibits metabolism in: - correct answer Statins
Route for atorvastatin: - correct answer PO
Onset, Peak, Duration for atorvastatin: - correct answer Onset: 2 weeks Peak: 1-2 hours Duration:
unknown
Cholestyramine Pharm. Class: - correct answer Bile Acid Sequestrant
Cholestyramine Therapeutic Class: - correct answer Antihyperlipidemic
Cholestyramine Pharmacokinetics: - correct answer Absorption - no
Distribution - no
Metabolized - no
Excretion - stool
Cholestyramine Action: - correct answer binds to bile acids & increases LDL receptors on hepatocytes
(causes a decrease in LDL)
Cholestyramine Indications: - correct answer Hypercholesterolemia
, Cholestyramine Admin: - correct answer Mix with 60-180 mL of WATER, NONCARBONATED beverages,
highly liquid soups, or pulpy fruits (applesauce, crushed pineapple). Drink immediately. DONT TAKE
WITH OTHER MEDS.
Serious Adverse Effects for Cholestyramine: - correct answer GI obstruction, metabolic acidosis, mal-
absorption syndrome; bleeding tendency
Contraindications for cholestyramine: - correct answer GI disorders, triglyeride levels > 400 mg/dl,
Pregnancy Category B
Drug interactions with cholestyramine: - correct answer Increase effects: Warfarin, anticoagulants by
decreasing levels of vitamin K.
Decrease effects: Digoxin, penicillin, Fe supplement, thyroid hormone, & thiazide diuretics
Nursing Interventions for Cholestyramine: - correct answer evaluate therapeutic outcomes 1 month of
therapy, dissolve completely before admin., dont take with other meds
Niacin Action: - correct answer decreases production of VLDL, which lowers serum triglyceride and LDL,
and increases HDL
Niacin adverse effects: - correct answer flushing, rash, diarrhea, hepatotoxicity, hyperglycemia,
hyperuricemia
Niacin Admin instructions: - correct answer take aspirin 30 minutes prior to reduce flush
Niacin Therapeutic Class: - correct answer B-Complex vitamin (B3)
Niacin Uses: - correct answer Clients at risk for pancreatitis and elevated triglyceride levels
Niacin Contraindications: - correct answer Pregnancy, liver disease, gout, DM, asymptomatic
hyperuricemia, peptic ulcer disease
