Teratogens (Well-enlightened)

Anticonvulsant embryopathy ie: Phenytoin, trimethadione, carbamazepine, valproate, barbiturates correct answers increased risk of birth defects 2-3X increase in SAB maternal fetal hypoxia & acidosis, preeclampsia preterm Hypertelorism, Broad depressed nasal bridge, Short nose with anteverted nares, "Cupid's bow" lip,Fingernail hypoplasia Increased risk for major malformations-- Meningomyelocele, Oral clefts, Congenital heart defects, Limb defects Developmental delay, most significantly with valproic acid Fetal alcohol exposure correct answers smooth philtrum, midface hypoplasia, depressed nasal thin palpebral fissures and upper lip microcephaly, CHD, IUGR FFT, ID, ADHD, psychomotor cocaine correct answers vascular disruptions, cranial defects, limb reduction, urogenital abn, GI abn, SAB, IUGR, preterm, placental abruption, uterine rupture SB, neonatal intraventricular hemmorage cigarettes correct answers IUGR, low birthweight, preterm (similar to marijuana) marijuana correct answers IUGR, low birth weight, preterm diabetes correct answers CHD (TOGA, ASD, VSD, TOF) GI (anorectal atresia, situs inversus, duodenal atresia) GU (renal agenesis, single umb art, cryptorchidism) CNS (NTD, microcephaly) skeletal (caudal regression, vertebral defect) IUFD, CL+/- CP, eye anomaly accutane correct answers microtia, anotia, cardiovascular&thymus defect, CNS,DD Thalidomide correct answers Limb reduction defects. First man made teratogen face, eyes, ears, genitalia, and internal organs, including heart, kidney, and gastrointestinal tract. psychotherapeutics: benzodiazepine correct answers clefting??? Neonatal adaptation like SSRIs Lithium correct answers cardiac ie Epstein anomaly Antidepressants: SSRIs (Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac) Paroxetine (Paxil, Pexeva) Sertraline (Zoloft) correct answers low risk, short term neonatal Irritability