UNE Biochem week 1 quiz with complete solutions.

UNE Biochem week 1 quiz with complete solutions. An enzyme has a mutation within the substrate binding site that reduces the binding of the coenzyme needed for covalent catalysis. Which of the following is likely to result as a consequence of this mutation? - correct enzyme will not be able to form the transition state complex Covalent catalysis is used by many enzymes to cleave peptide bonds. Which of the following amino acids would not facilitate this type of catalysis? (Think of the structure of the R-group of these amino acids) - correct answers.Valine The R-group on valine does not have an active group to participate in covalent catalysis. The most commonly participating amino acids are cysteine, serine and histidine. A 55-year old man is brought to the emergency room with a chief complaint of chest pain and tingling in his left arm. Elevation of which of the following enzymes in circulation would be most indicative of a myocardial infarction? - correct answers.Troponin MI is diagnosed by elevation of troponin, cardiac specific troponins would be the most accurate answer for this diagnosis. Amylase and lipase would indicate pancreatitis; elevation of lactate dehydrogenase is non-specific for muscle damage. Although LDH may be elevated, in the case of an MI it would not be a definitive indicator. Prosthetic groups are complex nonprotein molecules that participate in catalysis by providing functional groups that form a covalent intermediate between the enzyme and