USMLE STEP 1 PATHOLOGY Questions and Answers with Complete Solutions 2024

USMLE STEP 1 PATHOLOGY Questions and Answers with Complete Solutions 2024 Anticentromere antibodies - ANSScleroderma (CREST) Antidesmoglein (epithelial) antibodies - ANSPemphigus vulgaris (blistering) Anti-glomerular basement membrane antibodies - ANSGoodpasture's syndrome (glomerulonehpritis and hemoptysis) Antihistone antibodies - ANSDrug-induced SLE (hydralazine, isoniazid, phenytoin, procainamide) Anti-IgG antibodies - ANSRheumatoid arthritis (systemic inflammation, joint pannus, boutonniere deformity) Antimitochondrial antibodies (AMAs) - ANSPrimary biliary cirrhosis (female, cholestasis, portal hypertension) Antineutrophil cytoplasmic antibodies (ANCAs) - ANSVasculitis (c-ANCA: Wegener's; p-ANCA: microscopic polyangiitis, Churg-Strauss syndrome) Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA) - ANSSLE (type III hypersensitivity) Antiplatelet antibodies - ANSIdiopathic thrombocytopenic purpura (ITP) Anti-topoisomerase antibodies - ANSDiffuse systemic scleroderma Anti-transglutamniase/anti-gliadin/anti-endomysial antibodies - ANSCeliac disease (diarrhea, distension, weight loss) "Apple core" lesion on abdominal x-ray - ANSColorectal cancer (usually left- sided) Azurophilic granular needles in leukemic blasts - ANSAuer rods (acute myelogenous leukemia, especially the promyelocytic [M3] type) Bacitracin response - ANSSensitive: Streptocococcus pyogenes (group A) Resistant: Streptococcus agalactiae (group B) "Bamboo spine" on x-ray - ANSAnkylosing spondylitis (chronic inflammatory arthritis: HLA-B27) Basophilic nuclear remnants in RBCs - ANSHowell-Jolly bodies (due to splenectomy or nonfunctional spleen) Basophilic stippling of RBCs - ANSLea