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A 14-year-old patient has nonspecific complaints about pain in his or her legs. The physical examination is unremarkable. Laboratory results are within normal limits except for a markedly elevated alkaline phosphatase level. The psychiatric-mental health nurse practitioner - interprets the findings as normally occurring during a rapid adolescent growth spurt Laboratory findings for a patient with an alcohol use disorder indicate increased liver function values and: - increased MCV and elevated triglyceride levels. A new patient arrives at the office for treatment for depression. The patient reports taking simvastatin (Zocor) and lisinopril (Zestril). When selecting an antidepressant, the psychiatric-mental health nurse practitioner eliminates fluoxetine (Prozac), based on the knowledge that the combination can lead to increased plasma levels of the statin, resulting in an increased risk of muscle damage and rhabdomyolysis. The nurse practitioner's reason is that: - one medication is a CYP450 3A4 substrate and one is a CYP450 3A4 inhibitor.