Medical Biochemistry Exam 3 Qs&As A+

Medical Biochemistry Exam 3 Qs&As A+ Lipoproteins Functions - ANS-Keep their component lipids soluble as they transport them in the plasma Transport fat soluble vitamins such as A and E Lipoprotein Structure - ANS-Contain triacylglycerols, cholesterol, phospholipids, and proteins (apolipoproteins) Lipoprotein Core - ANS-Cholesteryl esters and TGs Lipoprotein Outer Layer - ANS-Phospholipids, free cholesterol (nonesterified), apolipoproteins B (apoB) ApoB is embedded but ApoC and ApoE are only loosely bound so they can be exchanged between different particles Apolipoproteins - ANS-Structural and Metabolic functions on lipoproteins Determine metabolic fate of lipoprotein particles through interactions with cellular receptors Regulate the activity of enzymes involved in lipid transport and distribution - ApoCII will activate LPL ApoCII activates - ANS-Lipoprotein lipase Classes of Lipoproteins - ANS-Chylomicrons Low Density Lipoproteins High Density Lipoproteins Very Low Density Lipoproteins Remnant particles (chylomicron remnants and VLDL remnants/IDL (intermediate density lipoproteins) - TG rich LDL - ANS-Bad cholesterol Beta lipoprotein Mainly cholesterol Includes: B100 Low TAG HIGHEST cholesterol Negative charge HDL - ANS-Good Cholesterol Alpha-lipoprotein Mainly protein Includes: AI, AII (C, E) LOWEST TAG High cholesterol Negative charge - will travel farthest with electrophoresis since it is also the smallest VLDL - ANS-Pre-Beta Lipoprotein Mainly TG Includes: B100 (A, C, E) High TAG Low cholesterol Negative charge Chylomicrons - ANS-Mainly TAG Includes: B48 (A,C, E) HIGHEST TAG LOWEST Cholesterol Neutral charge CONTINUES...