PC707 Final Safety Exam| 143 Questions and Answers (Graded A+)

Tetracycline - ANSWER-PRE: Photosensitivity, do not take with milk CONTRX: Not in pregnancy, not in children under 8yo (unless indication such as Rocky Mountain Spotted fever) ***Teeth discoloration, deposition on bones, bone growth restrictions Vitamin A - ANSWER-Caution: Pregnancy, childbearing age ***Can be teratogenic in excess Grapefruit Juice - ANSWER-CYP-3A4 inhibitor! Leads to increased pharmacologic effect of drugs (i.e. statins, some BP meds, Viagra) Phenobarbitol - ANSWER-CYP-2A's CYP-2C's inducer Leads to decreased pharmacologic effects of several drugs Tegretol - ANSWER-Caution taking concurrently with estrogen OCPs Caution in pregnancy Increases CYP-450 system and increases metabolism and excretion of estrogen, increasing risk of pregnancy Warfarin - ANSWER-Caution stopping prior to surgery when also on Dilantin Caution with fluconazole (Diflucan), TMP-SMZ (Bactrim), Increases open protein binding sites, reducing free-drug levels of Dilantin, increasing risk for seizure 98% of warfarin is protein bound any other protein binding drugs can essentially double concentration of free warfarin - May increase bleeding time Rifampin / Griseofulvin - ANSWER-Caution with combined OCPs CYP-450 inducer, leading to increased clearance of COC Combined Oral Contraceptive (COC) - ANSWER-Caution with anticonvulsants (lamotrigine), theophylline, Valium, TCAs, lithium CYP-450 inducer - may increase anticonvulsant (etc.) dose while active COC, but if COC has 7 days placebo, then lamotrigine will return to normal dose Antiretrovirals - ANSWER-Caution with COCs May increase or decrease COC - may increase side effects of estrogen or decrease overall effectiveness