PC707 Final Safety Exam| 380 Questions and Answers 100% Correct(RATED A+)

Grapefruit Juice - ANSWER-CYP450 inhibitor PCN contraindications - ANSWER-hx type 1 PCN allergy caution in hx of cephalosporin allergy PCN can ___________ the effects of warfarin - ANSWER-increase (increase bleeding risk) Tetracycline contraindications - ANSWER-pregnancy lactation children under 8 they bind to the calcium in bones and teeth resulting in yellow or brown discoloration and hypoplasia of the tooth enamel may also occur. Tetracyclines may decrease the effectiveness of _______________ - ANSWER-oral contraceptives • Tetracyclines have the potential to cause _________________ of the liver. - ANSWER-fatty infiltration What foods can interfere with tetracyclines? - ANSWER-chelation metals- Ca, Iron- medicine will be bound up and wont get good effects What precautions should someone take when on tetracyclines? - ANSWER-Avoid long expsoure to sunlight and wear protective clothing tetracyclines can cause you to get sunburns more easily drink lots of water to prevent crystals forming in urine Tetracyclines may increase the activity of ________________ - ANSWER-warfarin Are fluoroquinolones safe during pregnancy or lactation? - ANSWER-No Are fluoroquinolones safe for children? - ANSWER-No, not under age 18 If someone has underlying ___________ or ________________, you should use fluoroquinolones with caution. - ANSWER-Use with caution in underlying CNS pathology and renal impairment. can cause seizures What is the black box warning for fluoroquinolones? - ANSWER-risk for tendon rupture When taking levofloxacin (levaquin), a fluoroquinolone, what patients in particular have increased risk of tendon rupture? - ANSWER-individuals over 60 years of age, those taking corticosteroids, and patients with organ transplants. Aside from tendon rupture, what are other potential side effects of levofloxacin (levaquin)? - ANSWER-Potential side effects include non-reversible peripheral neuropathy, hepatotoxicity, hematologic disorders and seizures, anxiety, confusion, and depression. Fluoroquinolones can cause harm to which organ? For this reason, what precautions should prescribers take? - ANSWER-Evaluate liver function before initiating fluoroquinolone (FQ) therapy, and avoid prescribing these antibiotics for patients at increased risk for hepatotoxicity. Fluoroquinolones can cause - ANSWER-QT prolongation Are fluoroquinolones prone to drug-drug interactions? - ANSWER-Yes