NUR 641E Midterm Study Guide latest updated

NUR 641E Midterm Study Guide latest updated Prodrug - ️️ An inactive drug dosage form that is converted to an active metabolite by various biochemical reactions once it is inside the body. -Cytochrome P450 -Ex. Aspirin, psilocybin, heroin Bioavailability - ️️ the rate at and the extent to which a nutrient is absorbed and used -Affected by route of administration and drug dosage -Drug clearance (rate drug leaves circulation) -Steady state concentration -Affected by chemical stability, solubility, and first pass Steady state (of a drug) - ️️ stable level of drug in the body, occurs in 5 half lives of the drug -rate of drug being added to system is equal to amount being eliminated from system Pharmacokinetics - ️️ The process by which drugs are absorbed, distributed within the body, metabolized, and excreted. -what the body does to the drug First pass - ️️ the fact that a medication in the GI tract passes through the liver before entering other organs does not - ️️ bioequivalence does/does not affect bioavailability Bioequivalence - ️️ relative therapeutic effectiveness of chemically equivalent drugs. Bioavailability (is affected by) - ️️ -chemical instability