BMTCN Types of Transplants and Sources of Stem Cells fully solved graded A+ 2023/2024

BMTCN Types of Transplants and Sources of Stem Cells 3 types of Transplants - correct answer -Autologous -Allogeneic -Syngeneic 3 Sources of Stem Cells - correct answer -Peripheral Blood -Bone Marrow -Umbilical Cord Blood Autologous - correct answer -removing stem cells from the pt with the intent to reinfuse the cells at a later date -before they are able to have their stem cells collected, pts undergo testing to ensure they are disease free or have MRD -cryopreserved until needed (can be stored indefinitely.) -lethal dose of chemo is given to pt prior to stem cell infusion (prep/conditioning) -stem cells are given post conditioning to rescue hematopoietic function of bone marrow after being destroyed by lethal doses of chemo. Advantages of Auto Transplant - correct answer -easily available source -decreased risk of side effects -early engraftment -low risk of GVHD Disadvantages of Auto Transplant - correct answer -contamination of stem cells by undetectable disease cells -no change of immunologic effect of graft-vs-tumor to assist with control of relapse Allogeneic Transplant - correct answer -process of infusing donor stem cells into a recipient. -main types of allogeneic transplants are matched related and matched unrelated. -matched related are of genetic relation to a patient (mostly siblings) -matched unrelated are found through a national database -the degree of match is very important in relation to morbidity and mortality. If an appropriate match is not available other treatment options may be chosen. -haploidentical (half matched-related) -UCB Advantages of Allo Transplant - correct answer -disease free stem cell source -potential for GVT effect Disadvantages of Allo Transplant - correct answer -increased risk of side effects related to polypharmacy required post transplant -medications needed that are related to transplant -GVHD both acute and chronic -lifestyle changes related to ongoing risks of side effects Sygeneic Transplant - correct answer -uses stem cells from an identical twin