NR546 Week 2: Test Your Knowledge Quiz

Pharmacokinetics - the study of what happens to a drug from the time of administration until the parent drug and all metabolites leave the body Pharmacokinetics concepts - absorption distribution metabolism excretion Flockhart Table - drug interactions that are mediated by cytochrome P450 enzymes comprehensive list of drugs and the interactions related to the cytochrome P450 system client factors that impact the effect of psychotropic medications - -age -diet -smoking status -other prescribed medications -over-the-counter medications *all impact drug metabolism Neurotransmitters - chemicals released by neurons to send communication across synaptic clefts to other neurons -impact human emotion and behavior Many psychiatric disorders and client symptoms occur from an excess, deficiency, or imbalance of _________ - neurotransmitters Neurotransmission: - the chemical transmission of information between neurons and their target cells -the chemicals, or neurotransmitters, are released from their transport vesicles to bind with receptor sites to perform their duties, which are excitatory or inhibitory -neurotransmitter then either returned and stored for future use (reuptake) or inactivated and dissolved by enzymes Excitatory neurotransmitters: - increase the likelihood that the neuron will fire an action potentialinhibitory neurotransmitters: - decrease the likelihood that a neuron will fire an action neurotransmitters that most impact mental health can be classified into four major categories: - cholinergics -acetylcholine monoamines -norepinephrine, dopamine, serotonin, histamine amino acids -gamma- amino-butyric acid and glutamate neuropeptides Inhibitors: VISA CKGQ - Valproate Isoniazid Sulfonamides Amiodarone Chloramphenicol Ketoconazole Grapefruit Juice Quinidine -decrease medication metabolism Inducers: CRAP GPS - Carbamazepine Rifampin Alcohol Phenytoin Griseofulvin Phenobarbital Sulfonylureas -increase medication metabolism neurotransmitters that may be responsible for a client's symptoms of depression - Imbalanced levels of acetylcholine, norepinephrine, serotonin, histamine, or glutamate can contribute to symptoms of depressionclient who is a poor metabolizer: - has a lower concentration of the necessary enzyme to metabolize a drug, which results in higher blood concentrations of the drug. -increase the risk of side effects and adverse reactions